Edahiro Y, Kirito K, Gotoh A, Takenaka K, Sugimoto Y, Komatsu N, Shimoda K, A cross-sectional survey of symptoms and daily living among patients with polycythemia vera and their treating physicians in Japan, Hematology, 2023; 28(1): 2227817.
Suzuki K, Watanabe N, Torii S, Arakawa S, Ochi K, Tsuchiya S, Yamada K, Kawamura Y, Ota S, Komatsu N, Shimizu S, Ando M, Takaku T , Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations, bioRxiv, 2023; doi: 10. 1101/ 2023. 07. 26. 550632.
Edahiro Y, Ochiai T, Hashimoto Y, Morishita S, Shirane S, Inano T, Furuya C, Koike M, Noguchi M, Usuki K, Shiratsuchi M, Nakajima K, Ohtsuka E, Tanaka H, Kawata E, Nakamae M, Ueda Y, Aota Y, Sugita Y, Ohara S, Yamasaki S, Asagoe K, Yoshida S, Yamanouchi J, Suzuki S, Kondo T, Kanisawa Y, Toyama K, Omura H, Mizuchi D, Sakamaki S, Ando M, Komatsu N , Clinical characteristics of Japanese patients with Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, International journal of hematology, 2023; 118: 47-53.
Mori Y, Araki M, Morishita S, Imai M, Edahiro Y, Ito M, Ochiai T, Shirane S, Hashimoto Y, Yasuda H, Ando J, Ando M, Komatsu N, Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non-neoplastic erythrocytosis patients, Cancer Med., 2023; 12(2): 1079-1089.
Tokuhira M, Kimura Y, Tabayashi T, Watanabe N, Tsuchiya S, Takaku T, Iriyama N, Sato E, Nakazato T, Mitsumori T, Ishikawa M, Fujita H, Kizaki M, Ando M, Hatta Y, Iwanaga E, Kawaguchi T, Clinical management of second-generation tyrosine kinase inhibitor therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase, focusing on age and dose effects, Int J Hematol, 2023; 118(2): 210- 220.
Miyake M, Tsuyama N, Togashi Y, Noguchi M, tsukada N, Mishima Y, Takeuchi K, Eosinophil-rich variant of nodal marginal zone lymphoma: a clinicopathological study of 11 case, Histopathology, 2023; https://doi.org/10.1111/his.14963.
Kaneko T, Miyazaki S, Kurita A, Morimoto R, Tsuchiya S, Watanabe N, Takaku T, Komatsu N, Minamino T, Endothelial function measured by peripheral arterial tonometry in patients with chronic myeloid leukemia on tyrosine kinase inhibitor therapy: a pilot study , Cardiooncology, 2023; 9(1): 11.
Sato S, Ishii M, Tachibana K, Furukawa Y, Toyota T, Kinoshita S, Azusawa Y, Ando J, Ando M, Establishment of ganglioside GD2-expressing extranodal NK/T cell lymphoma cell line with scRNA-seq analysis, Experimental Hematology, 2023; S0301-472X(23)01769-1. doi: 10.1016.
Liu C, Imai M, Edahiro Y, Mano S, Takei H, Nudejima M, Kurose A, Morishita S, Ando M, Tsuneda S, Araki M, Komatsu N, Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms, Exp Hematol, 2023; 118: 12-20.
Tsuchiya K, Kimura K, Ai T, Yamamoto T, Nagasaka K, Takemura H, Edahiro Y, Saito K, Horiuchi Y, Misawa S, Takaku T, Ando J, Ando M, Miida T, Uchihashi K, Tabe Y, Evaluation of bone marrow aspirates using the automated hematology analyzer Sysmex XN-3000, International journal of laboratory hematology, 2023; 45(4); 460-468. doi: 10. 1111/ ijlh. 14058.
Yasuda H, Ando J, Yoshida S, Ota Y, Komatsu N, Ando M, Diffuse Large B-cell Lymphoma with Adrenal Involvement Presenting as Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorders: Sustained Remission with Methotrexate Termination Alone in Two Cases, Intern Med., 2023; 62(4): 601-604.
Iizuka-Honma H, Mitsumori T, Yoshikawa S, Takizawa H, Noguchi M, Factors Associated With Survival in Patients With End-of-Life Hematological Malignancies Who Received Chemotherapy: A Retrospective Single-Institution Study, Am J Hosp Palliat Care, 2023; 40(8): 812-819.
Furuya C, Morishita S, Hashimoto Y, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N, Impact of non-driver gene mutations on thrombo-haemorrhagic events in ET patients, British Journal of Haematology, 2023; doi: 10.1111.
Furukawa Y*, Ishii M*, Ando J, Ikeda K, Igarashi J K, Kinoshita S, Azusawa Y, Toyota T, Honda T, Nakanishi M, Ohshima K, Masuda A, Yoshida E, Kitade M, Porteus M, Terao Y, Nakauchi H, Ando M *co-first author, iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer, Cell Reports Medicine, 2023; 4(12): 101327. doi: 10.1016.
Tsuchiya S, Takaku T, Watanabe N, Iriyama N, Kimura Y, Iwanaga E, Sugimoto KJ, Mitsumori T, Ishikawa M, Nakazato T, Fujita H, Sato E, Hatta Y, Asou N, Kizaki M, Tokuhira M, Ando M, Kawaguchi T, Management and Risk Factors for Pleural Effusion in Japanese Patients with Chronic Myeloid Leukemia Treated with First-line Dasatinib in Real-world Clinical Practice, Intern Med., 2023; 62(22): 3299-3303.
Furuya C, Hashimoto Y, Morishita S, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N , MPL gene mutation is a possible risk factor for thrombosis in patients with essential thrombocythemia in Japan, Hematology, 2023; 28(1): 1-7.
Wakita.S, Marumo A, Morita K, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Ueki T, Uoshima N, Kobayashi Y, Kawata E, Nakayama K, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Hagihara M, Uchiyama H, Uchida N, Kubota Y, Kimura S, Nagoshi H, Ichinohe T, Kurosawa S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Tashiro H, Sakaguchi M, Yui S, Arai K, Kitano T, Miyata M, Arai H, Kanda M, Itabashi K, Fukuda T, Kanda Y, Yamaguchi H, Mutational analysis of DNMT3A improves the prognostic stratification of patients with acute myeloid leukemia, Cancer science, 2023; 114(4): 1297-1308. doi: 10.1111/cas.15720.
Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K, Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model, Blood Cancer Journal, 2023; 13(1): 110. doi: 10.1038/s41408-023-00869-9.
Morishita S, Hashimoto Y, Furuya C, Edahiro Y, Ochiai T, Shirane S, Inano T, Yasuda H, Ando M, Araki M, Komatsu N, Non-driver gene mutation analysis in a large cohort of polycythemia vera and essential thrombocythemia, Eur J Haematol, 2023; 110(2): 131-136.
Rai S , Won Seog Kim, Ando K, Choi I, Izutsu K, Tsukamoto N, Yokoyama M, Tsukasaki K, Kurod J, Ando J, Hidaka M, Koh Y, Shibayama H, Uchida T, Deok Hwan Yang, Ishitsuka K, Ishizawa K, Jin Seok Kim, Hong Ghi Lee, Minami H, Hyeon Seok Eom, Kurosawa M, Jae Hoon Lee, Jong Seok Lee, Won Sik Lee, Nagai H, Shindo T, Dok Hyun Yoon, Yoshida S, Gillings M, Onogi H, Tobinai K, Oral HDAC inhibitor tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: phase IIb results, Haematologica, 2023; 108(3); 811- 821. doi: 10.3324/ haematol. 2022. 280996.
Ogama Y, Kumagai Y, Komatsu N, Araki M, Masubuchi N, Akiyoshi H, Matsuura T, Kirisako H, Kyoya A, Nomura F, Ohira Y, Yokokawa T, Yamamoto Y, Phase 1 Clinical Trial of PPMX-T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics, Clin Pharmacol Drug Dev, 2023; 12(6): 579-587.
Yasuda H, Kaga N, Taka H, Ochiai T, Yamana T, Miura Y, Ishii M, Sasaki M, Ando J, Ando M, Polatuzumab vedotin pharmacokinetics in a hemodialysis patient with diffuse large B-cell lymphoma, Cancer chemotherapy and pharmacology, 2023; doi: 10.1007/s00280-023-04593-w.
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M, Possible New Histological Prognostic Index for Large B-Cell Lymphoma, J Clin Med., 2023; 12: 6324.
Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K, Real-world clinical characteristics of post-essential thrombocythemia and post-polycythemia vera myelofibrosis, Ann Hematol, 2023; 103(1): 97-103. doi: 10.1007/s00277-023-05528-4.
Furuya C, Hashimoto Y, Morishita S, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N, Reevaluation of cardiovascular risk factors for thrombotic events in 580 Japanese patients with essential thrombocythemia, Journal of Thrombosis and Thrombolysis, 2023; 55(2): 263-272.
Jo T, Yoshihara S, Okuyama Y, Fujii K, Henzan T, Kahata K, Yamazaki R, Takeda W, Umezawa Y, Fukushima K, Ashida T, Yamada-Fujiwara M, Hanajiri R, Yonetani N, Tada Y, Shimura Y, Nishikii H, Shiba N, Mimura N, Ando J, Sato T, Nakashima Y, Ikemoto J, Iwaki K, Fujiwara S, Ri M, Nagamura-Inoue T, Tanosaki R, Arai Y, Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan, British journal of haematology, 2023; 202(2): 256-266. doi: 10.1111/ bjh. 18831.
Takizawa H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Mitsumori T, Nitta H, Iizuka-Honma H, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M, Role of TGF-beta1 and TNF-alpha1 produced by neoplastic cells in the pathogenesis of fibrosis in patients with hematologic neoplasms, J Clin Exp Hematop, 2023; 63: 83-89.
Pecquet C, Papadopoulos N, Balligand T, Chachoua I, Tisserand A, Vertenoeil G, Nédélec A, Vertommen D, Roy A, Marty C, Nivarthi H, Defour JP, El-Khoury M, Hug E, Majoros A, Xu E, Zagrijtschuk O, Fertig TE, Marta DS, Gisslinger H, Gisslinger B, Schalling M, Casetti IC, Rumi E, Pietra D, Cavalloni C, Arcaini L, Cazzola M, Komatsu N, Kihara Y, Sunami Y, Edahiro Y, Araki M, Lesyk R, Buxhofer-Ausch V, Heibl S, Pasquier F, Plo I, Vainchenker W, Kralovics R, Constantinescu SN, Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms, Blood, 2023; 141(8): 917-929.
Kinoshita R, Ishibashi M, Handa H, Sasaki M, Imai Y, Tanaka N, Ito S, Sunakawa-Kii M, Kaito Y, Asayama T, Komatsu N, Tanaka J, Odajima T, Sugimori H, Yamaguchi H, Inokuchi K, Tamura H, The levels of serum soluble CD86 are correlated with the expression of CD86 variant 3 gene and are prognostic indicators in patients with myeloma, Exp Hematol, 2023; 121: 38-47.e2.
Sekiguchi Y, Tsutsumi H, Gomyo A, Kudo M, Iizaki Y, Maseki N, Kawamura M, Kobayashi K, Nishimura Y, Kanda H, Nitta H, Noguchi M, Kobayashi H, Use of R-mini-CHP in combination with polatuzumab vedotin (pola-R-mini-CHP) as the primary treatment in ≥80-year-old cases with diffuse large B-cell lymphoma, J Clin Exp Hematop, 2023; 63: 262-265.
Asada N, Ando J, Takada S, Yoshida C, Usuki K, Shinagawa A, Ishizawa K, Miyamoto T, Iida H, Dobashi N, Okubo S, Honda H, Soshin T, Nishimura Y, Tsutsui A, Mukai H, Yamamoto K, Venetoclax plus low-dose cytarabine in patients with newly diagnosed acute myeloid leukemia ineligible for intensive chemotherapy: an expanded access study in Japan, Japanese journal of clinical oncology, 2023; 53(7): 595-603. doi: 10. 1093/ jjco/ hyad027.
英文総説
Noguchi M, My 40-year Career as a Hematologist – Facing Clinical Challenges and Changing My Research– Focus from Glycolipids to Therapy Resistance–. , Juntendo Medical Journal, 2023; 69(4): 293-299
Morishita S, Komatsu N, Diagnosis- and Prognosis-Related Gene Alterations in BCR::ABL1-Negative Myeloproliferative Neoplasms, Int J Mol Sci, 2023; 24(16): 13008
英文症例報告
Iizuka-Honma H, Takizawa H, Nitta H, Mitsumori T, Noguchi M, Development of rapidly fatal TAFRO syndrome-like features in a patient with essential thrombocythemia, J Clin Exp Hematop, 2023; 63(1): 32-36.
Higo R, Kojima M, Itoha S, Noguchi M, Izumi H, Takeuchi K, Primary diffuse large B-cell lymphoma of the Larynx. , Auris Nasus Larynx, 2023; 50(4): 632-636.
Iizuka-Honma H, Takizawa H, Mitsumori H, Okura H, Ishii H, Noguchi M , Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib: A Case Report, Intern Med., 2023; 62(3): 459-463.
Yasuda H, Hoshino Y, Ando J, Miyachi M, Osawa M, Hattori N, Ando M, Vitamin B6 Deficiency Polyneuropathy and Dermatitis, Am J Med., 2023; 136(1): e10-e11.
国際学会発表
Suzuki K, Watanabe N, Ochi K, Torii S, Yamada K, Kawamura Y, Shimizu S, Komatsu N, Ando M, Takaku T , Artificial Intelligence-Driven “Ghost Cytometry” Enables Label-Free Identification of Chronic Myeloid Leukemia Cells Through Mitochondrial Morphological Alterations, 25th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy, Mandelieu-La Napoule, France, October 7, 2023.
Ando M, CAR-T therapy for B-ALL and Lymphoma, 3rd Annual Meeting of the Ukrainian Professional Society of Paediatriconcology/haematology, Ukraine 7th Apr 2023 (Invited lecture, oral presentation, web).
Tanaka Y, DIAGNOSTIC DILEMMA BETWEEN PUBIC OSTEOLYSIS AND NEOPLASMS IN OSTEOLYTIC LESION OF THE PUBIS , 21st European Federation of Internal Medicine, Athens, Greece, March 16th, 2023.
Furukawa Y, Ishii M, Goto A, Kinoshita S, Ando J, Nakauchi H, Ando M, iPSC-derived CD4 T cell generation and investigation of CD4/CD8 T cell lineage choice, ASH2023, San Diego, USA, Dec 2023 (Poster presentation) Award.
Kinoshita S, Ishii M, Furukawa Y, Sato S, Ando J, Nakauchi H, Ando M, iPSC-derived dual antigen receptor T cells targeting GD2 and LMP2 antigens for extranodal NK/T cell lymphoma, nasal type, ASH2023, San Diego, USA, Dec 2023 (Poster presentation).
Ando M, Ishii M, Furukawa Y,Igarashi KJ, Kinoshita S, Azusawa Y, Terao Y, Ando J, Nakauchi H, iPSC-derived hypoimmunogenic T cells enriched with tissue resident memory T cells powerfully attack cervical cancer, ISSCR 2023 Annual Meeting, Boston, USA, June 2023 (oral presentation).
Edahiro Y, Kirito K, Gotoh A, Takenaka K, Sugimoto Y, Komatsu N, Shimoda K, The Impact of polycythemia vera on daily living, and symptom and treatment perception gaps between patients and physicians: results of a cross-sectional survey in Japan, EHA 2023 Hybrid Congress, Frankfurt & virtual, June 8-11, 2023.
三森 徹, Efficiency and safety of treatment with of polatuzumab vedotin, bendamustine, and rituximab（Pola-BR) for relapsed/refractory diffuse large B-cell lymphoma at single-center experience, 日本臨床腫瘍学会, 福岡, 2023年3月16日
Sakai K, Nakazawa H, Hirokawa M, Fujishima N, Yonemura Y, Arai S, Harigae H, Matsuda A, Komatsu N, Tohyama K, Nakao S, Kurokawa M, Mitani K, Ishida F, Impact of time to response to CsA/PSL in patients with PRCA: from interim analysis of PRCA2016, 第85回日本血液学会学術集会, 東京, 2023年10月13日(金)～15日(日)
Ando M, iPSC-derived dual antigen receptor T cell therapy for EBV-associated lymphomas, The 7th Tsurui Lymphoma Workshop, 釧路, 2023年2月24日
Suzuki K, Takaku T, Watanabe N, Ochi K, Torii S, Yamada K, Kawamura Y, Shimizu S, Komatsu N, Ando M , MAPK activation and Drp1 phosphorylation induce AI-detectable mitochondrial changes in CML cells, 第85回日本血液学会学術集会, 東京, 2023年10月14日
Imanaka R, Katsuoka Y, Uoshima N, Hara S, Ando J, Goto T, Ota S, Yoshimoto G, Matsuoka A, Hashiba H, Morita T, Tsutsui A, Numata H, Multicenter study of real-world experience of venetoclax for newly diagnosed AML in Japan (VENUS), 第85回日本血液学会学術集会, 東京, 2023年10月13〜15日（口演）
Shimoda K, Komatsu N, Matsumura I, Ikeda K, Hino M, Hidaka M, Maeda Y, Kondo T, Fujisaki T, Shoshi K, Azuma K, Fukushima R, Kawashima J, Kosugi H, Phase 3 study of momelotinib vs ruxolitinib in JAK inhibitor naive myelofibrosis patients in Japan, 第85回日本血液学会学術集会, 東京, 2023年10月13日(金)～15日(日)
Watanabe N, Takaku T, Iriyama N, Iwanaga E, Kimura Y, Ishikawa M, Nakayama H, Sato E, Tabayashi T, Mitsumori T, Nakazato T, Tokuhira M, Fujita H, Ando M, Hatta Y, Kawaguchi T , Usefulness of New Risk Prediction Model for VAEs in Japanese Patients with CML Treated with TKIs in a Practice-Based Stud, The 85th Annual Meeting of the Japanese Society of Hematology, 東京, 2023年10月14日
Ando J, Furukawa Y, Ishii M, Kinoshita S, Sato S, Tsukune Y, Yasuda H, Takaku T, Hamano Y, Sasaki M, Ando M, Venetoclax combinations in untreated and R/R AML with single-cell RNA-seq, TP53-mutated patients, 第85回日本血液学会学術集会, 東京, 2023年10月13 - 15日（口演）
Baba T, Hashimoto Y, Yasuda H, Araki M, Edahiro Y, Morishita S, Ochiai T, Shirane S, Ando J, Komatsu N, Validation and reliability of current guidelines for the treatment of essential thrombocythemia under real-world clinical settings in Japan, Hematology, 2022; 27(1): 157-166. doi: 10.1080/16078454.2021.2022848.
De Marchi F, Okuda M, Morishita S, Imai M, Baba T, Horino M, Mori Y, Furuya C, Ogata S, Yang Y, Ando J, Ando M, Araki M, Komatsu N, Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms, Leukemia research, 2022; 119: 106883. pii: S0145-2126(22)00109-6.
Edahiro Y, Ito T, Gotoh A, Nakamae M, Kimura F, Koike M, Kirito K, Wada H, Usuki K, Tanaka T, Mori T, Wakita S, Saito TI, Kada A, Saito AM, Shimoda K, Sugimoto Y, Kurokawa T, Tomita A, Hashimoto Y, Akashi K, Matsumura I, Takenaka K, Komatsu N, Clinical characteristics of Japanese patients with polycythemia vera: results of the JSH-MPN-R18 study, Int J Hematol, 2022; 116(5): 696-711.
Edahiro Y, Koike M, Nojiri S, Harada Y, Gotoh A, Fujibayashi K, Nishizaki Y, Yanagisawa N, Takaku T, Nitta H, Tsukune Y, MisawaK, Kobayashi H, Komatsu N, A pilot study examining the efficacy of hochuekkito for improving quality of life in patients with myeloproliferative neoplasms, Jpn J Clin Oncol, 2022; 52: 880-886.
Edahiro Y, Kurokawa Y, Morishita S, Yamamoto T, Araki M, Komatsu N, Causes of thrombocytosis: A single-center retrospective study of 1,202 patients, Intern Med, 2022;61(22):3323-3328.
Edahiro Y, Ohishi K, Gotoh A, Takenaka K, Shibayama H, Shimizu T, Usuki K, Shimoda K, Ito M, VanWart SA, Zagrijtschuk O, Qin A, Kawase H, Miyachi N, Sato T, Komatsu N, Kirito K, Correction to: Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study, Int J Hematol, 2022; 116(4): 642-643.
Edahiro Y, Ohishi K, Gotoh A, Takenaka K, Shibayama H, Shimizu T, Usuki K, Shimoda K, Ito M, VanWart SA, Zagrijtschuk O, Qin A, Kawase H, Miyachi N, Sato T, Komatsu N, Kirito K, Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study, Int J Hematol, 2022; 116(2): 215-227.
Furukawa Y, Hamano Y, Shirane S, Kinoshita S, Azusawa Y, Ando J, Nakauchi H, Ando M, Advances in allogeneic cancer cell therapy and future perspectives on “off-the-shelf” T cell therapy using iPSC technology and gene editing, Cells, 2022; 11(2): 269.
Furuya C, Hashimoto Y, Morishita S, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N, Reevaluation of cardiovascular risk factors for thrombotic events in 580 Japanese patients with essential thrombocythemia, Journal of Thrombosis and Thrombolysis, 2022; doi: 10.1007/s11239-022-02751-0.
Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N , Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma, Molecular therapy : the journal of the American Society of Gene Therapy, 2022; 30(2): 534-549. doi: 10.1016/j.ymthe.2021.10.006.
Hashimoto Y, Ito T, Gotoh A, Nakamae M, Kimura F, Koike M, Kirito K, Wada H, Usuki K, Tanaka T, Mori T, Wakita S, Saito TI, Kada A, Saito AM, Shimoda K, Sugimoto Y, Kurokawa T, Tomita A, Edahiro Y, Akashi K, Matsumura I, Takenaka K, Komatsu N, Clinical characteristics, prognostic factors, and outcomes of patients with essential thrombocythemia in Japan: the JSH-MPN-R18 study, International Journal of Hematology, 2022; 115(2): 208-221.
Iida S, Izumi T,Komeno T,Terui Y, Chou T, Ikeda T,Berg D,Fukunaga S,Sugiura K,Sasaki M, A phase 2, open-label, multicenter study of ixazomib plus lenalidomide and dexamethasone in adult Japanese patients with relapsed and/or refractory multiple myeloma, Int J Clin Oncol, 2022; 27(1): 224-233.
Iizuka K, Morishita S, Nishizaki Y, Iizuka Y, Iriyama N, Ochiai T, Yanagisawa N, Yasuda H, Ando J, Gotoh A, Takei M, Hatta Y, Nakamura H, Nakayama T, Komatsu N, von Willebrand factor activity levels are influenced by driver mutation status in polycythemia vera and essential thrombocythemia patients with well-controlled platelet counts, Eur J Haematol, 2022; 109(6): 779-786.
Iizuka-Honma H, Mitsumori T, Yoshikawa S, Takizawa H, Noguchi M, Factors Associated With Survival in Patients With End-of-Life Hematological Malignancies Who Received Chemotherapy: A Retrospective Single-Institution Study, Am J Hosp Palliat Care,2022; 10499091221142502.
Iizuka-Honma H, Mitsumori T, Yoshikawa S, Takizawa H, Noguchi M, Prognostic Value of Palliative Prognostic Index for Hospitalized Patients With End-of-Life Hematologic Malignancies in a Japanese University Hospital, JCO Oncol Pract, 2022; 18(1): e108-e116. doi: 10.1200/OP.21.00243.
Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Yang Y, Ito M, Osaga S, Mano H, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ando J, Komatsu N, Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia, Scientifc Reports, 2022; 12(1): 1115.
Kitamura H, Kubota Y, Tomimasu R, Akashi M, Mori T, Mine Y, Ando J, Murayama SY, Kimura S, Miyahara M, Non-valvular Infective Endocarditis Caused by Sarocladium kiliense in an Immunocompromised Patient with Aplastic Anemia, Internal medicine, 2022; 61(8): 1279-1283. doi: 10.2169/internalmedicine.7536-21.
Komatsu N, Hashimoto Y, Baba T, Otsuka M, Akimoto T, Fernandez J, Safety and efficacy of anagrelide in Japanese post-marketing surveillance, with subgroup analyses on the effect of previous cytoreductive therapies, age, and starting dose, Int J Hematol, 2022; 116(4): 570-578.
Liu C, Imai M, Edahiro Y, Mano S, Takei H, Nudejima M, Kurose A, Morishita S, Ando M, Tsuneda S, Araki M, Komatsu N, Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms, Experimental Hematology, 2022; 118: 12-20. doi: 10.1016/j.exphem.2022.11.005.
Marumo A, Wakita S, Morita K, Oh I, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Uoshima N, Kobayashi Y, Kawata E, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Hagihara M, Uchiyama H, Kubota Y, Kimura S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Date K, Fujiwara Y, Terada K, Yui S, Arai K, Kitano T, Miyata M, Ohashi K, Kanda Y, Yamaguchi H, NPM1-mutation-based measurable residual disease assessment after completion of two courses of post-remission therapy is a valuable clinical predictor of the prognosis of acute myeloid leukemia, International journal of hematology, 2022; 116(2): 199-214. doi: 10.1007/s12185-022-03328-6.
Mesa R, Komatsu N, Gill H, Jin J, Lee SE, Hou HA, Sato T, Qin A, Urbanski R, Shih W, Zagrijtschuk O, Zimmerman C, Verstovsek S, MPN-545 Surpass-ET: Ropeginterferon Alfa-2b (P1101) vs. Anagrelide as Second Line Therapy in Essential Thrombocythemia, Clin Lymphoma Myeloma Leuk, 2022; 22Suppl2: S342.
Mori Y, Araki M, Morishita S, Imai M, Edahiro Y, Ito M, Ochiai T, Shirane S, Hashimoto Y, Yasuda H, Ando J, Ando M, Komatsu N, Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non-neoplastic erythrocytosis patients, Cancer Med, 2022; 12(2):1079-1089. doi: 10.1002/cam4.4958.
Morishita S, Hashimoto Y, Furuya C, Edahiro Y, Ochiai T, Shirane S, Inano T, Yasuda H, Ando M, Araki M, Komatsu N, Non-driver gene mutation analysis in a large cohort of polycythemia vera and essential thrombocythemia, Eur J Haeato, 2022; 110(2): 131-136. doi: 10.1111/ejh.13882.
Nishiyama-Fujita Y, Nakazato T, Iriyama N, Tokuhira M, Ishikawa M, Sato E, Takaku T, Sugimoto K, Fujita H, Fujioka I, Tsuchiya S, Kimura Y, Iwanaga E, Komatsu N, Asou N, Kizaki M, Hatta Y, Kawaguchi T, Outcomes of adolescents and young adults with chronic-phase chronic myeloid leukaemia treated with tyrosine kinase inhibitors, Annals of Medicine, 2022; 54(1): 1244-1254.
Ogama Y, Kumagai Y, Komatsu N, Araki M, Masubuchi N, Akiyoshi H, Matsuura T, Kirisako H, Kyoya A, Nomura F, Ohira Y, Yokokawa T, Yamamoto Y, Phase 1 Clinical Trial of PPMX-T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics, Clin Pharmacol Drug Dev, 2022; doi: 10.1002/cpdd.1216. Online ahead of print.
Pecquet C, Papadopoulos N, Balligand T, Chachoua I, Tisserand A, Vertenoeil G, Nédélec A, Vertommen D, Roy A, Marty C, Nivarthi H, Defour JP, El-Khoury M, Hug E, Majoros A, Xu E, Zagrijtschuk O, Fertig TE, Marta DS, Gisslinger H, Gisslinger B, Schalling M, Casetti IC, Rumi E, Pietra D, Cavalloni C, Arcaini L, Cazzola M, Komatsu N, Kihara Y, Sunami Y, Edahiro Y, Araki M, Lesyk R, Buxhofer-Ausch V, Heibl S, Pasquier F, Plo I, Vainchenker W, Kralovics R, Constantinescu SN, Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms, Blood, 2022; 2022016846. doi: 10.1182/blood.2022016846.
Suzuki M, Koyama D, Ikeda S, Sukegawa M, Teshirogi M, MisawaK, Tsunoda S, Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy, J Clin Exp Hematop, 2022; 62(2): 91-98.
Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T, Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors, Nat Commun, 2022; 13(1): 271.
Tsuyama N, Noguchi M, Asaka R, Sakata S, Baba S, Izumi H, Takeuchi K, Hodgkinoid histiocytosis: an atypical nodal CD30 and S100-positive histiocytosis with eosinophilia, Histopathology, 2022; 81(3): 371-379. doi: 10.1111/his.14718.
Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S, In silico-labeled ghost cytometry, Elife, 2022; 10: e67660.
Verstovsek S, Komatsu N, Gill H, Jin J, Lee SE, Hou HA, Sato T, Qin A, Urbanski R, Shih W, Zagrijtschuk O, Zimmerman C, Mesa RA, SURPASS-ET: phase III study of ropeginterferon alfa-2b versus anagrelide as second-line therapy in essential thrombocythemia, Future Oncol, 2022; 18(27): 2999-3009.
Wakita S, Sakaguchi M, Oh I, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Ueki T, Uoshima N, Kobayashi Y, Kawata E, Tajika K, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Kayamori K, Hagihara M, Uchiyama H, Uchida N, Kubota Y, Kimura S, Nagoshi H, Ichinohe T, Kurosawa S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Marumo A, Omori I, Fujiwara Y, Terada K, Yui S, Arai K, Kitano T, Miyata M, Kurosawa A, Mizoguchi A, Komatsu N, Fukuda T, Ohashi K, Kanda Y, Inokuchi K, Yamaguchi H, Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia, Blood Advances, 2022; 6(1): 238-247. doi: 10.1182/bloodadvances.2021004292.
Watanabe N, Takaku T, Fujioka I, Tsuchiya S, Ando M, Bosutinib-induced late-onset severe liver injury preceded by eosinophilia, Ann Hematol, 2022; 101(10): 2257-2262.
Watanabe N, Takaku T, Tsukune Y, Yasuda H, Ochiai T, Yamada K, Nakazawa H, Hotta S, Nishimaki T, Takagi H, Takahashi K, Komatsu N, Ando M, Bosutinib-induced lung injury: a report of two cases and literature review, Int J Hematol, 2022; 115(6): 902-905.
Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia PJ, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann DM, Imai M, Komatsu N, Araki M, Tanaka Y, Sakai R, A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation, Nat Commun, 2022; 13(1): 7262.
Yamamoto K, Shinagawa A, DiNardo CD, Pratz KW, Ishizawa K, Miyamoto T, Komatsu N, Nakashima Y, Yoshida C, Fukuhara N, Usuki K, Yamauchi T, Asada N, Asou N, Choi I, Miyazaki Y, Honda H, Okubo S, Kurokawa M, Zhou Y, Zha J, Potluri J, Matsumura I, Venetoclax plus azacitidine in Japanese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy, Jpn J Clin Oncol, 2022; 52(1): 29-38.
Yasuda H, Furukawa Y, Nishioka K, Sasaki M, Tsukune Y, Shirane S, Hattori N, Ando M, Komatsu N, Vitamin B6 deficiency as a cause of polyneuropathy in POEMS syndrome: rapid recovery with supplementation in two cases, Hematology, 2022; 27: 463-468.
Yasuda H, Hatano T, Honda T, Tsutsui M, Hattori N, Ando M, Komatsu N, Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy forParkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts, Intern Med, 2022; 61(24): 3719-3722.
Yasuda H, Komatsu N, Ando J, Ando M, Hodgkin Lymphoma on Hemodialysis: A Review of Treatment and Recommendations, Clinical lymphoma, myeloma & leukemia, 2022; 22(11): 805-811. Pii: S2152-2650(22)00226-9.
Yasuda H, Tomizawa Y, Harada S, Sasaki M, Komatsu N, Ando J, Hattori N, Ando M, Anti-myelin-associated-glycoprotein neuropathy successfully treated with tirabrutinib, Heliyon, 2022; 8(10): e10928. doi: 10.1016/j.heliyon.2022.e10928.
Yokomizo T, Ideue T, Morino-Koga S, Cheng Yong Tham, Sato T, Takeda N, Kubota Y, Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, Suda T, Independent origins of fetal liver haematopoietic stem and progenitor cells, Nature, 2022; 609(7928): 779-784.
Yoshida C, Kondo T, Ito T, Kizaki M, Yamamoto K, Miyamoto T, Morita Y, Eto T, Katsuoka Y, Takezako N, Uoshima N, Imada K, Ando J, Komeno T, Mori A, Ishikawa Y, Satake A, Watanabe J, Kawakami Y, Morita T, Taneike I, Nakayama M, Duan Y, Guijarro B, Delgado A, Llamas C, Kiyoi H, Real-world treatment patterns and clinical outcomes in patients with AML in Japan who were ineligible for first-line intensive chemotherapy, International journal of hematology, 2022; 116(1): 89-101. doi: 10.1007/s12185-022-03334-8.
英文症例報告
Hasui H, Iseki T, Ueno Y, Kamiyama D, Miyamoto N, Kijima C, Hira K, Komatsu N, Hattori N, Recurrent and Multiple
Intracerebral Hemorrhages in Polycythemia Vera Secondary to Myelofibrosis: A Case Report and Literature Review, Case
Rep Neurol, 2022; 14(2): 274-280.
Higo R, Kojima M, Itoha S, Noguchi M, Izumi H, Takeuchi K, Primary diffuse large B-cell lymphoma of the Larynx,
Auris Nasus Larynx, 2022; 14: 50.
Iizuka-Honma H, Takizawa H, Mitsumori T, Okura H, Ishii H, Noguchi M, Refractory Primary Vitreoretinal Lymphoma
Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib, Intern Med, 2022; 62(3): 459-463. doi:
10.2169/internalmedicine.9591-22.
Inano T, Yasuda H,Tsukune Y, Tsutsui M, Wali N, Saeki H, Kajino K, Hino O, Masaki Y, Komatsu N, Abnormal
Exacerbation of Moderately Differentiated Gastric Adenocarcinoma in a Patient with TAFRO Syndrome: An Impaired Tumor
Immunity?, Case Rep Oncol, 2022; 15: 7-11.
Misawa K, Yasuda H, Matsuda H, Hara M, Ochiai T, Koyama D, Takano H, Iwao N, Koike M, Adult paroxysmal cold
hemoglobinuria following mRNA COVID-19 vaccination, eJHaem, 2022; 3: 992–995.
Misawa K, Yasuda H, Matsuda H, Hara M, Ochiai T, Koyama D, Takano H, Iwao N, Koike M, Development of Acute Adult
T-cell Leukemia Following PD-1 Blockade Therapy for Lung Cancer, Intern Med, 2022; 61(22): 3421-3424.
Sekiguchi Y, Ishikawa A, Kanda H, Kawamura M, Tomita S, Noguchi M, A Case of EBER Positive Angioimmunoblastic T-cell
Lymphoma Combined with Myxofibrosarcoma of the Pleura, Tokai J Exp Clin Med, 2022; 47(1): 1-8.
Shirane S, Najima Y, Fukushima K, Sekiya N, Funata N, Kishida Y, Nagata A, Yamada Y, Konishi T, Kaito S, Kurosawa S,
Yoshifuji K, Uchida T, Inamoto K, Shingai N, Toya T, Igarashi A, Shimizu H, Kobayashi T, Kakihana K, Sakamaki H,
Ohashi K, Horiguchi S, Hishima T, Doki N, Central nervous system mucormycosis in a patient with hematological
malignancy: A case report and review of the literature, J infect Chemother, 2022; 28(12): 1658-1662. doi:
10.1016/j.jiac.2022.08.003.
Uchimura A, Yasuda H, Ando J, Ota Y, Sasaki M, Takaku T,Tsukune Y, Tsutsui M, Edahiro Y, Watanabe N, Ochiai T,
Komatsu N, Ando M, Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab
Vedotin, Case Rep Oncol, 2022; 15: 263-266.
Watanabe N, Kitahara H, Honda T, Iwasaki H, Iwao N, Komatsu N, Koike M, High incidence of disseminated intravascular
coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei, J Clin Exp Hematop, 2022;
62(4): 249-252.
Yasuda H, Ando J, Yoshida S, Ota Y, Komatsu N, Ando M, Diffuse large B-cell lymphoma with adrenal involvement
presenting as other iatrogenic immunodeficiency-associated lymphoproliferative disorders: sustained remission with
methotrexate termination alone in two cases, Internal Medicine, 2022; doi: 10.2169/internalmedicine.0130-22.
Yasuda H, Hoshino Y, Ando J, Miyachi M, Osawa M, Hattori N, Ando M, Vitamin B6 deficiency polyneuropathy and
dermatitis, The American Journal of Medicine, 2022; S0002-9343(22): 00717-3.
国際学会発表
Ando M, Single-institution experience in unfit AML treated with Venetoclax, Educational Course on Acute Myeloid Leukemia(AML), MD Anderson Cancer Center Preceptorship in Japan, Tokyo, Aug 20-21 2022.
Kaito Y, Sugimoto E, Nakamura F, Tsukune Y, Sasaki M, Yui S, Yamaguchi H, Goyama S, Nannya Y, Mitani K, Tamura H, Imai Y, DNAM-1/Tigit/CD155/CD112 Axis Is a Novel Target of NK-Cell Therapy in Acute Myeloid Leukemia, 64th American Society of Hematology Annual Meeting & Exposition, Orlando, USA, December 10-13 2022.
Kirito K, Edahiro Y, Ohishi K, Gotoh A, Takenaka K, Shibayama H, Shimizu T, Usuki K, Shimoda K, Ito M, VanWart S, Zagrijtschuk O, Qin A, Kawase H, Miyachi N, Sato T, Komatsu N, Phase 2, open-label, multicenter, single-arm study investigating the efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera , EHA2022 Congress, Vienna(Hybrid), June 10 2022.
Marumo A, Wakita S, Morita K, Kako S, Toya T, Najima Y, Doki N, Kanda J, Kuroda J, Mori S, Satake A, Usuki K, Ueki T, Uoshima N, Kobayashi Y, Kawata E, Nakayama K, Nagao Y, Shono K, Shibusawa M, Tadokoro J, Hagihara M, Uchiyama H, Uchida N, Kubota Y, Kimura S, Nagoshi H, Ichinohe T, Kurosawa S, Motomura S, Hashimoto A, Muto H, Sato E, Ogata M, Mitsuhashi K, Ando J, Tashiro H, Sakaguchi M, Yui S, Arai K, Kitano T, Miyata M, Fukuda T, Kanda Y, Yamaguchi H, Mutational Analysis of DNMT3A Improves the Prognostic Stratification Using NPM1/FLT3-ITD Genotypes in Patients with Acute Myeloid Leukemia, The 64th American Society of Hematology Annual Meeting, New Orleans, December 10-13 2022. Poster Session #158686
Sasaki M, Suzuki K, Abe Y, Ito S, Nishiwaki K, Handa H, Chou T, Soeda J, Mori I, Shinozaki T, Takezako N, Efficacy and safety of ixazomib plus lenalidomide and dexamethasone following injectable proteasome inhibitor-based therapy in patients with relapsed/refractory multiple myeloma, 27th European Hematology Association 2022 annual meeting, Vinena Austria +hybrid, Jun 15-17 2022.
Takezako N, Suzuki K, Abe Y, Ito S, Nishiwaki K, Handa H, Chou T, Soeda J, Mori I, Shinozaki T, Sasaki M, Efficacy and safety of ixazomib plus lenalidomide and dexamethasone following injectable proteasome inhibitor-based therapy in patients with relapsed/refractory multiple myeloma, 19th International Myeloma Society Annual Meeting, LA California, Aug 25-27 2022.
Uchimura A, Efficient use of blinatumomab for a patient with recurrent Philadelphia chromosome-positive acute lymphoblastic leukemia after multiple allogenic hematopoietic-cell transplantations, EBMT 7th International Transplantation Course, Bercelona, September 3 2022.
和文総説
枝廣 陽子, 日本における骨髄増殖性腫瘍のreal world data, 臨床血液, 2022; 63(9): 1083-1091.
Baba T, Masubuchi N, Morishita S, Shioiri K, Kihara Y, Ando M, Araki M, Komatsu N, Endogenous expression of MPLW515L showed a weak oncogenic capacity in UT-7/TPO cells, 第84回日本血液学会学術集会, 福岡, 2022年10月14日(金)～16日(日)
Edahiro Y, Hsiao H-H, Tanaka H, Ikeda T, Fujii M, Ono K, Okubo S, Potluri J, Yeh S-P, Safety and tolerability of navitoclax plus ruxolitinib in patients with myelofibrosis, 第84回日本血液学会学術集会, 福岡, 2022年10月15日
Furukawa Y, Ando J, Ishii M, Kinoshita S, Ando M, A novel extranodal NK/T-cell lymphoma, nasal type cell line, ENKL-J1, 第84回日本血液学会学術集会, 福岡, 2022年10月15日
Furuya C, Hashimoto Y, Morishita S, Ando M, Komatsu N, 日本人のMPL変異陽性本態性血小板血症の臨床的特徴についてーMPL変異はJAK2V617F変異と同様に血栓症のリスク因子であるー, 第84回日本血液学会学術集会, 福岡, 2022年10月14日
Furuya C, Hashimoto Y, Morishita S, Ando M, Komatsu N, 本態性血小板血症における,心血管リスク因子と血栓症発症との関連性についてー高トリグリセリド血症は血栓症の強いリスク因子であるー, 第84回日本血液学会学術集会, 福岡, 2022年10月14日
Honda A, Toyama K, Oyama Y, Matsuda K, Mizuno H, Saito A, Katayama Y, Komatsu N, Kurokawa M, Prognostic factors of idiopathic hypereosinophilic syndrome: A nationwide survey in Japan, 第84回日本血液学会学術集会, 福岡, 2022年10月14日(金)～16日(日)
Iwakiri M, Nagata Y, Sheng J, Marumo A, Sakaguchi M, Arai K, Kitano T, Miyata M, Wakita S, Kuroda J, Nagao Y, Tadokoro J, Uchiyama H, Kimura S, Motomura S, Sato E, Ogata M, Mitsuhashi K, Ando J, Kanda J, Kawata E, Doki N, Mori S, Uoshima N, Kako S, Kanda Y, Shono K, Satake A, Yamaguchi H, The clinical and genetic features of Japanese de novo AML with IDH1/2 and SRSF2 mutations., 第84回日本血液学会学術集会, 福岡, 2022年10月16日
Morishita S, De Marchi F, Okuda M, Imai M, Baba T, Mori Y, Furuya C, Ogata S, Yang Y, Ando J, Ando M, Araki M, Komatsu N, Clinical relevance of CREB3L1 expression in Ph-negative MPN, 第84回日本血液学会学術集会, 福岡, 2022年10月14日(金)～16日(日)
Sheng J, Nagata Y, Marumo A, Sakaguchi M, Arai K, Kitano T, Miyata M, Wakita S, Kuroda J, Nagao Y, Tadokoro J, Uchiyama H, Kimura S, Motomura S, Sato E, Ogata M, Mitsuhashi K, Ando J, Kanda J, Kawata E, Doki N, Mori S, Uoshima N, Kako S, Kanda Y, Shono K, Satake A, Yamaguchi H, Clinical impact of IDH1/2 mutations in AML patients treated with Venetoclax, 第84回日本血液学会学術集会, 福岡, 2022年10月14日
Shirane S, Hamano Y, Uchimura A, Mori Y, Tsutsui M, Ando M, 脾照射の影響が示唆された同種造血幹細胞移植後の肝類洞閉塞症候群3例, 第84回日本血液学会学術集会, 福岡, 2022年10月14日
Cervantes F, Ross DM, Radinoff A, Palandri F, Myasnikov A, Vannucchi AM, Zachee P, Gisslinger H, Komatsu N, Foltz L, Mannelli F, Passamonti F, Gilotti G, Sadek I, Tiwari R, Zor E, Al-Ali HK, Efficacy and safety of a novel dosing strategy for ruxolitinib
in the treatment of patients with myelofibrosis and anemia: the REALISE phase 2 study, Leukemia, 2021 Dec; 35(12): 3455-3465.
Edahiro Y, Yasuda H, Gotoh A, Morishita S, Suzuki T, Takeda J, Ando J, Tsutsui M, Itakura A, Komatsu N, Interferon therapy for pregnant patients with essential thrombocythemia in Japan, Int J Hematol, 2021 Jan; 113(1): 106-111.
Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N, Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell
therapy for refractory lymphoma, Molecular Therapy, in press, 2021.
Ikeda S, Tsunoda S, Koyama D, Suzuki M, Sukegawa M, Misawa K, Hojo H, Zhu X, Utano K, Ohta M, Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma, J Clin Exp Hematop, 2021
Jun; 61(2): 78-84.
Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Yang Y, Ito M, Osaga S, Mano M, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ando J, Komatsu N, Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential
thrombocythemia, Scientific Reports, 2021 Sep; 11(1): 17702.
Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M, iPSC-derived neoantigen-specific cytotoxic T-lymphocyte therapy for Ewing sarcoma, Cancer Immunology Research, 2021; 9(10):
1175-1186.
Kinoshita S, Ando M, Ando J, Ishii M, Furukawa Y, Tomita O, Shirane S, hito Kishita Y, Yatsuka Y, Eguchi H, Okazaki Y, Komatsu N, Trigenic ADH5 / ALDH2 / ADGRV1 mutations in myelodysplasia with Usher syndrome, Heliyon, 2021; 7(8): e07804.
Komatsu N, Arita K, Mitsui H, Nemoto T, Hanaki K, Efficacy and safety of ferric citrate hydrate compared with sodium ferrous citrate in Japanese patients with iron deficiency anemia: a randomized, double-blind, phase 3 non-inferiority study, Int J Hematol,
2021 Jul; 114(1): 8-17.
Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Ito M, Araki M, Komatsu N, CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome-negative myeloproliferative
neoplasms, Cancer Sci, 2021 Feb; 112(2): 884-892.
Morishita S, Ochiai T, Misawa K, Osaga S, Inano T, Fukuda Y, Edahiro Y, Ohsaka A, Araki M, Komatsu N, Clinical impacts of the mutational spectrum in Japanese patients with primary myelofibrosis, eron therapy for pregnant patients with essential thrombocythemia
in Japan, Int J Hematol, 2021 Apr; 113(4): 500-507.
Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, Hosoya N, Hiramoto N, Ishikawa T, Branford S, Shanmuganathan N, Ohyashiki K, Takahashi N, Takaku T, Tsuchiya S, Kanemura N, Nakamura N, Ueda Y, Yoshihara S, Bera R, Shiozawa Y, Zhao L,
Takeda J, Watatani Y, Okuda R, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Takaori-Kondo A, Miyano S, Ogawa S, Shih LY, Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia,
Nat Commun, 2021 May 14; 12(1): 2833.
Ohara K, Kinoshita S, Ando J, Azusawa Y, Ishii M, Harada S, Mitsuishi Y, Asao T, Tajima K, Yamamoto T, Takahashi F, Komatsu N, Takahashi K, Ando M, SCLC-J1, a novel small cell lung cancer cell line, Biochem Biophys Rep, 2021 Jul; 27: 101089.
Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Uemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki Mi, Takizawa H, Fukuyama T, Lamagna C, Masuda E, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T, Eliminating
chronic myeloid leukemia stem cells by IRAK 1/4 inhibitors, Nature Communications, in press, 2021
Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S, In silico-labeled
ghost cytometry Elife, 2021 Dec; 10: e67660.
Watanabe N, Gao S, Wu Z, Batchu S, Kajigaya S, Diamond C, Alemu L, Raffo DQ, Hoffmann P, Stone D, Ombrello AK, Young NS. Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes, J Leukoc Biol. 2021
Sep; 110(3): 409-424.
Yamauchi T, Yoshida C, Usuki K, Takada S, Matsumura I, Dobashi N, Miyazaki Y, Miyamoto T, Iida H, Asou N, Kuroda J, Ichikawa S, Komatsu N, Mendes W, Honda H, Okubo S, Kurokawa M, Jiang Q, Wei A, Ishizawa K, Venetoclax plus low-dose cytarabine in Japanese
patients with untreated acute myeloid leukaemia ineligible for intensive chemotherapy, Jpn J Clin Oncol, 2021 Aug; 51(9): 1372-1382.
Yasui H, Kobayashi M, Sato K, Kondoh K, Ishida T, Kaito Y, Tamura H, Handa H, Tsukune Y, Sasaki M, Komatsu N, Tanaka N, Tanaka J, Kizaki M, Kawamata T, Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for
multiple myeloma relapse, Int J Clin Oncol, 2021 Nov; 26(11): 2142-2150.
英文総説
Yasuda H, Yasuda M, Komatsu N, Chemotherapy for non-Hodgkin lymphoma in the hemodialysis patient: A comprehensive review, Cancer Sci, 2021 Jul; 112(7): 2607-2624.
英文著書
Ando M, Kinoshita S, Furukawa Y, Ando J, Nakauchi H, Brenner MK: Advances in stem cell biology, volume 12, Molecular Players in iPSC Technology, Elsevier, 2021, Chapter 3, Improving the safety of iPSC-derived T cell therapy, 95-115.
英文症例報告
Ando J, Ueno Y, Yasuda H, Ando M, Edahiro Y, Honda T, Takanashi M, Taniguchi D, Hattori N, Komatsu N, Radiation-Induced Myopathy Developing in a Hodgkin Lymphoma Patient: An Autopsy Case with Systemic Muscle Sampling, Case Rep Oncol, 2021 Mar; 14(1):
338-342.
Edahiro Y, Takaku T, Suzuki M, Fukuda Y, Harada S, Kinoshita S, Inano T, Shirane S, Hamano Y, Kondo A, Komatsu N, Intravascular large B-cell lymphoma as a recurrence of primary central nervous system lymphoma after chemotherapy: A case report, Leuk Res
Rep, 2021 May; 15: 100249.
Fukumura Y, Taniguchi G, Koyanagi A, Horiuchi Y, Ochiai T, Tabe Y, Sano K, Maimaitiaili Y, Otsuji N, Ashizawa K, Yao T, A Case of Untreated Myeloid Sarcoma of the Pancreas Head Region: Diagnostic Process of AML Subtyping in an Autoptic Case, Case Rep
Pathol, 2021
Furukawa Y, Ando J, Ando M, Kinoshita S, Edahiro Y, Furuta T, Ohshima K, Komatsu N, Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma, J Clin Exp Hematop, 2021 Sep; 61(3): 168-172.
Furukawa Y, Ando M, Azusawa Y, Kinoshita S, Harada S, Ochiai T, Honda T, Sugimoto K, Tabe Y, Komatsu N, Ando J, Persistent immune thrombocytopaenic purpura associated with SARS-CoV-2 infection, EJHaem, 2021 May; 2(3), 530-533.
Harada S, Ando J, Ando M, Azusawa Y, Ochiai T, Hashimoto Y, Hirasawa Y, Komatsu N, Sarcoma-like appearance but pathologic Hodgkin lymphoma, Int J Hematol, 2021 Jul; 114(1): 1-2.
Harada S, Ando J, Ando M, Nitta H, Inano T, Hirasawa Y, Furukawa Y, Kinoshita S, Kondo A, Ohshima K, Komatsu N, High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy, Intern Med, 2021 Dec; 60(23): 3795-3799.
Haraguchi M, Harada N, Watanabe J, Yoshikawa H, Shirai Y, Komura M, Koyama M, Ito J, Tsukune Y, Horimoto Y, Hayashi T, Nagaoka T, Uekusa T, Takahashi K, Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC
syndrome/GATA2 mutation: a case report, BMC Infect Dis, 2021; 21: 502.
Iizuka H, Harada S, Iwao N, Koike M, Noguchi M, Primary Skeletal Muscle Peripheral T-cell Lymphoma: An Autopsy Case Report and Review of the Literature,Internal medicine, 2021; 60(20): 3309-3315.
Iizuka H, Mori Y, Iwao N, Koike M, Noguchi M, Hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus-positive diffuse large B-cell lymphoma, NOS of bone marrow-liver-spleen type: an autopsy case report, Journal of clinical and experimental
hematopathology, 2021 Jun; 61(2): 102-108.
Iizuka H, Mori Y, Fukuda Y, Iwao N, Koike M, Noguchi M, Two autopsy cases of pulmonary leukemic infiltration mimicking severe pneumonia in patients with acute myeloid leukemia, Leukemia Research Reports, 2021; 16: 100269.
Kinoshita S, Ando J, Ando M, Komatsu N, Primary Lymphoma of the Pericardium, Intern Med, 2021 Dec; 60(24): 4005-4006.
Mori T, Abe H, Yoshida M, Tsukune Y, Yahata Y, Takaku T, Ando J, Ando M, Torii S, Sasaki M, Immunohistochemical detection of aflatoxin in lesions of aflatoxin-producing Aspergillus flavus infection, Medical Mycology Journal, 2021; 62(3): 47-52.
Takahashi M, Makino S, Iizuka H, Noguchi M, Yoshida K, Chronic active Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis in pregnancy: a case report, lBMC Pregnancy Childbirth, 2021; 21: 681.
Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K, Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient
with Multiple Myeloma Complicated with POEMS Syndrome, Intern Med, 2021; 60: 3625-3630.
Sekiguchi Y, Nishitani M, Takizawa H, Iizuka H, Mitsumori T, Noguchi M, Sawada T, Yoshikawa S, Okubo T, Okubo M, Yoshikawa S, A Case of CCR4-Positive, Localized Primary ATLL of the Bone, Ann Case Report, 2021; 6: 650.
Shirane S, Watanabe D, Sekiya N, Horiguchi S, Najima Y, Paraplegia via hematogenous dissemination of Cunninghamella elegans (mucormycosis) after hematopoietic stem cell transplantation, Int J Infect Dis, 2021 Dec; 113: 210-212.
Takahashi M, Makino S, Iizuka H, Noguchi M, Yoshida K, Chronic active Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis in pregnancy: a case report, lBMC Pregnancy Childbirth, 2021; 21: 681.
Yamashita Y, Takahashi Y, Tsunemi T, Shirane S, Nakazato-Taniguchi T, Taniguchi D, Takanashi M, Sasaki M, Komatsu N, Hattori N, Systemic sclerosis precedes POEMS syndrome, Can J Neurol Sci, 2021 May; 48(3): 446-449.
Yasuda H, Morishita S, Mori Y, Tsukune Y, Inano T, Harada S, Komatsu N, JAK2/CALR/SF3B1 triple-mutated myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis evolving to myelofibrosis and SF3B1 single-mutated acute myeloid
leukemia: evidence of a pre-JAK2 clone, Leuk Res, 2021 Jan; 100: 106496.
Yasuda H, Tsukune Y, Tadaaki Inano, Yosuke Mori, Yasunori Ota, Komatsu N, Successful long-term ibrutinib treatment in a hemodialysis patient with leukemic non-nodal mantle cell lymphoma, Clin Lymphoma Myeloma Leuk, 2021 Feb; 21(2): e176-e178.
Yasuda H, Mori Y, Chiba A, Bai J, Murayama G, Matsushita Y, Miyake S, Komatsu N, Resolution of one-year persisting COVID-19 pneumonia and development of immune thrombocytopenia in a follicular lymphoma patient with preceding rituximab maintenance therapy:
a follow-up report and literature review of cases with prolonged infections, Clin Lymphoma Myeloma Leuk, 2021 Oct; 21(10): e810-e816.
国際学会発表
Ando M, Ando J, Ishii M, Honda T, Kinoshita S, Furukawa Y, Masuda A, Kitade M, Terao Y and Nakauchi H, iPSC-derived "off-the-shelf" CTL therapy for cervical cancers.
ISSCR International Symposium Tokyo 2021, Tokyo, Japan, 29th Oct, 2021 (oral presentation)
Ishii M, Ando J, Toyota T, Ohara K, Nakauchi H, Ando M, iPSC-derived neoantigen-specific cytotoxic T lymphocyte therapy for Ewing sarcoma, ISSCR 2021, Virtual (poster), 21 June - 26 June, 2021
Mesa RA, Komatsu N, Gill H, Jin J, Lee SE, Hou HA, Sato T, Qin A, Urbanski R, Shih W, Zagrijtschuk O, Zimmerman C, Verstovsek S, Surpass-ET Trial: A Phase 3, Open-Label, Multicenter, Randomized, Active-Controlled Study to Assess Pharmacokinetics and Compare
the EJcacy, Safety, and Tolerability of P1101 Vs Anagrelide As Second Line Therapy for Essential Thrombocythemia 63nd ASH, December 11, 2021
Sekiguchi Y, Iizuka H, Takizawa H, Mitsumori Tet, al, Use of Ibrutinib in 10 Patients with Treatment-Naïve or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Real-World Clinical Practice -A Report from a Single Medical Institution,
癌と化学療法, 2021 Jul; 48(7): 921-926.
Sekiguchi Y, Nishitani M, Takizawa H, Iizuka H, Mitsumori T, et al, Low-Risk Essential Thrombocythemia Who Presented with Recurrent Episodes of Cerebral Hemorrhage during Pregnancy and Developed Cerebral Infarction during Puerperium, 癌と化学療法, 2021 May;
48(5): 725-730.
Hiromi Watari, Hiromu Kageyama, Hiroya Nakajia, Kako Onodera, Nami Masubuchi, Takumi Oshiro, Takashi Matui, Yoshio Kodera, Tomohisa Ogawa, Makoto Hirayama, Kanji Hori, Takeshi Yokoyama, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai, Marine
sponge lectin reveals the mechanism of sugar-chain mediated activation of MPL , 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)～25日(土)
Kaoko Sakai, Hideyuki Nakazawa, Makoto Hirokawa, Naohito Fujishima, Yuji Yonemura, Shunya Arai, Hideo Harigae, Akira Matsuda, Norio Komatsu, Kaoru Tohyama, Shinji Nakao, Mineo Kurokawa, Kinuko Mitani, Fumihiro Ishida, One third of the patients with acquired
chronic PRCA show macrocytic anemia: data from PRCA2016, 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)～25日(土)
Kazuya Sugimoto, Miki Ando, Jun Ando, Midori Ishii, Yoko Azusawa, Yoshiki Furukawa, Shintaro Kinoshita, Tadahiro Honda, Sakiko Harada, Hiromitsu Nakauchi, Norio Komatsu, Development of iPSC-derived Tax-specific CTL therapy for adult T-cell leukemia/lymphoma,
第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)～25日(土)
Norio Komatsu, Terumi Baba, Manami Otsuka, Takafumi Akimoto, Jovelle Fernandez, Safety and efficacy of anagrelide from post-marketing surveillance data in Japan, 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)～25日(土)
Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto K.J, Fujita H, Kimura Y, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, Kawaguchi T. The EUTOS long-term survival score predicts disease-specific mortality and molecular responses
among patients with chronic myeloid leukemia in a practice-based cohort. Cancer Med 2020;9(23):8931-8939.
Shuhei Kurosawa , Noriko Doki, Yasushi Senoo, Yuya Kishida, Akihito Nagata, Yuta Yamada, Tatsuya Konishi, Satoshi Kaito, Kota Yoshifuji, Naoki Matsuyama, Shuichi Shirane, Tomoyuki Uchida, Kyoko Inamoto, Takashi Toya, Aiko Igarashi, Yuho Najima, Hideharu
Muto, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi. Bone turnover markers as an aid to monitor osteoporosis following allogeneic hematopoietic stem cell transplantation. Annals of hematology 2020; 59(16):1947-1956.
Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Ito M, Araki M, Komatsu N. CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome-negative myeloproliferative
neoplasms. Cancer Sci 2020.
Masuda A, Isobe Y, Sugimoto K, Yoshimori M, Arai A, Komatsu N. Efficient recruitment of c-FLIPL to the death-inducing signaling complex leads to Fas resistance in natural killer-cell lymphoma. Cancer Sci 2020; 111(3):807-816.
Masubuchi N, Araki M, Yang Y, Hayashi E, Imai M, Edahiro Y, Hironaka Y, Mizukami Y, Kihara Y, Takei H, Nudejima M, Koike M, Ohsaka A, Komatsu N. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia
2020;34(2):499-509.
Makoto Murata, Ritsuro Suzuki, Tetsuya Nishida, Shuichi Shirane, Yutaka Shimazu, Yosuke Minami, Takehiko Mori, Noriko Doki, Yoshinobu Kanda, Naoyuki Uchida, Masatsugu Tanaka, Jun Ishikawa, Kazuto Togitani, Takahiro Fukuda, Tatsuo Ichinohe , Yoshiko Atsuta,
Tokiko Nagamura-Inoue, Hitoshi Kiyoi. Allogeneic Hematopoietic Stem Cell Transplantation for Post-essential Thrombocythemia and Post-polycythemia Vera Myelofibrosis. Internal Medicine 2020; 28(11): 2394-2405,
Komatsu N, Jun G, Yonezu T, Ohashi Y. Real-world, retrospective study evaluating thromboembolic events, associated risk factors, and health-care resource utilization in Japanese patients with polycythemia vera. Int J Hematol 2020; 112(2):176-184.
Ishibashi M, Takahashi R, Tsubota A, Sasaki M, Handa H, Imai Y, Tanaka N, Tsukune Y, Tanosaki S, Ito S, Asayama T, Sunakawa M, Kaito Y, Kuribayashi-Hamada Y, Onodera A, Moriya K, Komatsu N, Tanaka J, Odajima T, Sugimori H, Inokuchi K, Tamura H. SLAMF3-mediated
signaling via ERK pathway activation promotes aggressive phenotypic behaviors in multiple myeloma. Mol Cancer Res 2020; 18: 632-43.
Honda T, Ando M, Ando J, Ishii M, Sakiyama Y, Ohara K, Toyota T, Ohtaka M, Masuda A, Terao Y, Nakanishi M, Nakauchi H, Komatsu N. Sustainable tumor suppressive effect of iPSC-derived rejuvenated T cells targeting cervical cancers. Mol Cancer Res 2020;
18: 632-43.
Edahiro Y, Yasuda H, Gotoh A, Morishita S, Suzuki T, Takeda J, Ando J, Tsutsui M, Itakura A, Komatsu N. Interferon therapy for pregnant patients with essential thrombocythemia in Japan. Int J Hematol 2020; in press
Edahiro Y, Yasuda H, Ando K, Komatsu N. Self-limiting pregnancy-associated pure red cell aplasia developing in two consecutive pregnancies: case report and literature review. Int J Hematol 2020;111(4):579-584.
Araki M, Komatsu N. The role of calreticulin mutations in myeloproliferative neoplasms. Int J Hematol 2020;111(2):200-205.
Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N. Long-term eradication of extranodal Natural killer /T-cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr
virus-specific rejuvenated T cells in vivo. Haematologica 2020;105(3):796-807.
Ando M, Ando J, Honda T, Ishii M, Nakauchi H, Komatsu N. iPSC-derived rejuvenated T cell therapy for extranodal NK/T-cell lymphoma, nasal type. Juntendo Medical Journal 2020; 66: 200-205,
Ando J, Ueno Y, Yasuda H, Ando M, Edahiro Y, Honda T, Takanashi M, Taniguchi D, Hattori N, Komatsu N. Radiation induced myopathy developing in a Hodgkin lymphoma patient: an autopsy case with systemic muscle sampling. Case Reports in Oncology 2020; in
press
Ando J, Ngo MC, Ando M, Leen A, Rooney CM. Identification of protective T-cell antigens for smallpox vaccines. Cytotherapy 2020;22(11):642-652,
Yasuda H, Tsukune Y, Watanabe N, Sugimoto K, Uchimura A, Tateyama M, Miyashita Y, Ochi Y, Komatsu N. Persistent COVID-19 Pneumonia and Failure to Develop Anti-SARS-CoV-2 Antibodies During Rituximab Maintenance Therapy for Follicular Lymphoma. Clin Lymphoma
Myeloma Leuk, 2020; 20(11):774-776
Yasuda H, Tsukune Y, Inano T, Mori Y, Ota Y, Komatsu N. Successful Long-Term Ibrutinib Treatment in a Hemodialysis Patient With Leukemic Nonnodal Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk 2020.
Yamashita Y, Takahashi Y, Tsunemi T, Shirane S, Nakazato-Taniguchi T, Taniguchi D, Takanashi M, Sasaki M, Komatsu N, Hattori N. Systemic Sclerosis Precedes POEMS Syndrome. Can J Neurol Sci 2020:1-4.
Semba R, Horimoto Y, Arakawa A, Edahiro Y, Takaku T, Iijima K, Saito M, Difficulty Diagnosing a Brain Tumor during Clinical Maintenance of a Complete Response to anti-HER2 Treatments for Metastatic Breast Cancer: A Case Report. Case Rep Oncol. 2020; 23;13(3):1311-1316
Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Araki M, Komatsu N. 3082CREB3L1Overexpression Can Reliably Discriminate Ph-MPNs from Reactive Cases. 62nd ASH, Dec7.
Kihara Y, Araki M, Imai M, Mori Y, Mei H, Ogata S, Yoshikawa S, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Fukuda Y, Morishita S, Suzuki T, Domae N, Shimonaka M, Akazawa C, Ohsaka A, Komatsu N. 716Therapeutic Potential of an Antibody Targeting the Cleaved
Form of Mutant Calreticulin in Myeloproliferative Neoplasms. 62nd ASH, 7 Dec.
Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Ito M, Osaga S, Yang Y, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N. 2177 Concomitant Occurrence of Polyclonal Hematopoiesis and Cell-Autonomous Megakaryopoiesis in Triple-Negative
Essential Thrombocythemia. 62nd ASH, 6 Dec.
Yokomizo T, Ideue T, Araki K, Kurokawa M, Komatsu N, Osato M, Suda T. In vivo tracing of hematopoietic stem and progenitor cell formation in the mouse embryo. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Yasuda S, Aoyama S, Yoshimoto R, Watanabe D, Yamamoto K, Fujiwara T, Edahiro Y, Imai M, Araki M, Komatsu N, Miura O, Kawamata N. Overexpression of MPL causes ruxolitinib-resistance in MPN with CALR frame-shift mutations. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Tsuchiya S, Takaku T, Fujioka I, Watanabe N, Iriyama N, Sato E, Nakazato T, Kimura Y, Sugimoto K, Fujita H, Ishikawa M, Iwanaga E, Hatta Y, Asou N, Kizaki M, Komatsu N, Tokuhira M, Kawaguchi T. Risk factors and management of pleural effusion in the dasatinib
treated Japanese CML patients. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Tokuhira M, Kimura Y, Iriyama N, Tsuchiya S, Takaku T, Fujita Y, Nakazato T, Sato E, Sugimoto K, Fujita H, Ishikawa M, Fujioka I, Hatta Y, Komatsu N, Asou N, Kizaki M, Iwanaga E, Kawaguchi T. C linical results of dasatinib treatment in elderly patients
with newly diagnosed CML-CP. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Tokuhira M, Kimura Y, Fujita Y, Nakazato T, Ishikawa M, Sugimoto K, Iriyama N, Tsuchiya S, Takaku T, Fujita H, Sato E, Fujioka I, Asou N, Hatta Y, Komatsu N, Kizaki M, Iwanaga E, Kawaguchi T. Clinical results of nilotinib treatment in elderly patients
with newly diagnosed CML-CP. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Takaku T, Tsuchiya S, Endo D, Tsutui M, Nitta H, Kajimoto K, Amano A, Komatsu N. The development of primary cardiac large B cell lymphoma during the treatment for CML. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Shioiri K, Araki M, Kitazawa S, Masubuchi N, Morishita S, Imai M, Ohsaka A, Komatsu N. Analysis of behavior of erythropoietin receptor on the cell surface in JAK2 mutant cells. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Shibayama H, Itagaki M, Handa H, Yokoyama, Sawamura M, Kosugi S, Minauchi K, Nakamura D, Shimazu Y, Sugiura I, Fuchida S, Iino M, Shimizu T, Moriuchi Y, Toyama K, Mitani K, Tsukune Y, Kada A, Tamura H, Abe M, Iwasaki H, Kuroda J, Takamatsu H, Sunami K,
Kizaki M, Ishida T, Saito T, Matsumura I, Akashi K, Iida S. Patient demographics in a prospective observational study of plasma cell neoplasms in Japan. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Sato E, Aritaka N, Kitahara H, Masuda A, Ochiai T, Kinoshita S, Ota Y, Hirano T, Komatsu N. Bortezomib therapy of Waldenstrom's macroglobulinemia with simultaneous IgM and IgG paraproteinemia. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Ochiai T, Sato E, Sugimoto K, Tsunoda A, Fukai T, Komatsu N. Successful treatment Sezary syndrome with bexarotene monotherapy. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Moriyama M, Akahane D, Moriya S, Yamada A, Imai M, Araki M, Komatsu N, Miyazawa K, Gotoh A. Targeting ER stress enhances inhibitory effect of ruxolitinib in mutated-CALR transfected cells. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Araki M, Komatsu N. CREB3L1 overexpression as a novel diagnostic marker of myeloproliferative neoplasms. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Misawa K, Furukawa Y, Fujioka I, Iwao N, Komatsu N, Koike M. Characteristics of the elderly patients with AML in the Juntendo Shizuoka Hospital. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Kinoshita R, Ishibashi M, Handa H, Sasaki M, Komatsu N, Imai Y, Ito S, Tanaka N, Tanaka J, Isoda A, Matsumoto M, Tanosaki S, Sunakawa M, Asayama T, Inokuchi K, Tamura H. FGFR3 overexpression was not associated with poor survival in t(4;14)+ multiple myeloma
patients. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Kihara Y, Araki M, Imai M, Fukuda Y, Mori Y, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Mizukami Y, Morishita S, Akazawa C, Ohsaka A, Komatsu N. Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin. 第82回日本血液学会学術集会,
Web, 10月10日～11月8日.
Fukuda Y, Takaku T, Furuya C, Shirane S, Edahiro Y, Hamano Y, Komatsu N. Two cases of R-CHOP therapy combined with eltrombopag for treatment DLBCL complicated with AA. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
Edahiro Y, Takaku T, Fukuda Y, Harada S, Kinoshita S, Inano T, Shirane S, Hamano Y, Komatsu N. The development of IVLBCL after the treatment for PNCSL. 第82回日本血液学会学術集会, Web, 10月10日～11月8日.
特別講演・招待講演
安藤純. 第1部 キムリア治療における治療提供可能施設間の連携. KYMRIAH Network Meeting in Tokyo, 2020
安藤純. キムリア Up to date 〜最新の知見を踏まえて〜. KYMRIAH Web Seminar from Tokyo, 2020
小松則夫. 骨髄増殖性腫瘍の治療最前線～本態性血小板血症を中心に～. 甲信越 MPN e-Conference WEB 11月6日.
2019年
英文原著
Yokomizo T, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen D G, Osato M, Suda T, Komatsu N. Hlf marks the developmental pathway for hematopoietic stem
cells but not for erythro-myeloid progenitors. J Exp Med 2019;216(7):1599-1614.
Yasuda H, Tsutsui M, Ando J, Inano T, Noguchi M, Yahata Y, Tanaka M, Tsukune Y, Masuda A, Shirane S, Misawa K, Gotoh A, Sato E, Aritaka N, Sekiguchi Y, Sugimoto K, Komatsu N. Vitamin B6 deficiency is prevalent in primary and secondary myelofibrosis patients.
Int J Hematol 2019;110(5):543-549.
Tsukune Y, Sasaki M, Komatsu N. Reactivation of Hepatitis B Virus in Patients with Multiple Myeloma. Cancers (Basel) 2019;11(11):1819.
Tsukune Y, Sasaki M, Isoda A, Ando J, Koike M, Matsumoto M, Sawamura M, Tamura H, Handa H, Imai Y, Yahata Y, Komatsu N. Safety of lenalidomide, dexamethasone, and cyclophosphamide in elderly Japanese patients with relapsed and refractory multiple myeloma:
results of phase 1 study. International Journal of Myeloma 2019;9(2):1-6.
Sugiyama M, Ueno Y, Kamo H, Edahiro Y, Miyamoto N, Yamashiro K, Tanaka R, Shimo Y, Komatsu N, Hattori N. Specific mechanisms of subarachnoid hemorrhage accompanied by ischemic stroke in essential thrombocythemia: two case reports and a literature review.
J Neurol 2019;266(8):1869-1878.
Maekawa T, Kato S, Kawamura T, Takada K, Sone T, Ogata H, Saito K, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Horiuchi T, Hikota-Saga R, Endo-Umeda K, Uno S, Osawa Y, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita
S, Araki M, Makishima M, Komatsu N, Kimura F. Increased SLAMF7 high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab. Blood 2019;134(10):814-825.
Kimura K, Tabe Y, Ai T, Takehara I, Fukuda H, Takahashi H, Naito T, Komatsu N, Uchihashi K, Ohsaka A. A novel automated image analysis system using deep convolutional neural networks can assist to differentiate MDS and AA. Sci Rep 2019;9(1):13385.
Ishikawa M, Iriyama N, Tokuhira M, Takaku T, Sato E, Sugimoto K-J, Nakazato T, Fujita H, Kimura Y, Fujioka I, Komatsu N, Asou N, Kizaki M, Hatta Y, Kawaguchi T. Potential role for second-generation tyrosine kinase inhibitors in patients with chronic myeloid
leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis. Oncol Rep 2019;42(6):2836-2843.
Iriyama N, Tokuhira M, Sato E, Sugimoto K-J, Takaku T, Ishikawa M, Nakazato T, Fujita H, Kimura Y, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, Kawaguchi T. Smoking influences the outcomes of patients receiving tyrosine kinase inhibitors for chronic
myeloid leukemia in the chronic phase: A retrospective analysis. Hematol Oncol 2019;37(3):323-325.
Inano T, Araki M, Morishita S, Imai M, Yasuda H, Nitta H, Ito M, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N. JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive
mutation to polycythaemia vera. Br J Haematol 2019;187(1):e27-e31.
Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H. NUP98-HBO1-fusion generates phenotypically and genetically
relevant chronic myelomonocytic leukemia pathogenesis. Blood Adv 2019;3(7):1047-1060.
Hatsumi N, Miyawaki S, Yamauchi T, Takeshita A, Komatsu N, Usui N, Arai Y, Ishida F, Morii T, Kano Y, Ogura M, Machida S, Nishii K, Honda S, Ohnishi K, Naoe T. Phase II study of FLAGM (fludarabine + high-dose cytarabine + granulocyte colony-stimulating
factor + mitoxantrone) for relapsed or refractory acute myeloid leukemia. Int J Hematol 2019;109(4):418-425.
Gerds A T, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. Corrigendum to "Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis
previously treated with ruxolitinib" [Leukemia Res. 79 (2019) 38-44]. Leuk Res 2019;81:10
Gerds A T, Tauchi T, Ritchie E, Deininger M, Jamieson C, Mesa R, Heaney M, Komatsu N, Minami H, Su Y, Shaik N, Zhang X, DiRienzo C, Zeremski M, Chan G, Talpaz M. Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously
treated with ruxolitinib. Leuk Res 2019;79:38-44.
Fukuda Y, Araki M, Yamamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Yasuda H, Gotoh A, Ohsaka A, Komatsu N. Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy. Haematologica
2019;104(11):e506-e509.
Edahiro Y, Araki M, Inano T, Ito M, Morishita S, Misawa K, Fukuda Y, Imai M, Ohsaka A, Komatsu N. Clinical and molecular features of patients with prefibrotic primary myelofibrosis previously diagnosed as having essential thrombocythemia in Japan. Eur
J Haematol 2019;102(6):516-520.
Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia 2019;33(1):122-131.
Yamasaki S, Nitta H, Kondo E, Uchida N, Miyazaki T, Ishiyama K, Kiyota M, Matsuoka H, Ichinohe T, Fukuda T, Atsuta Y, Suzumiya J, Suzuki R. Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective
study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation. Ann Hematol 2019;98(9):2213-2220.
Kurosawa S, Sekiya N, Doki N, Yaguchi T, Kishida Y, Nagata A, Yamada Y, Konishi T, Kaito S, Yoshifuji K, Shirane S, Uchida T, Inamoto K, Toya T, Igarashi A, Najima Y, Muto H, Kobayashi T, Kakihana K, Sakamaki H, Ohashi K. The emergence of rare nocardiosis
following allogeneic hematopoietic stem cell transplantation in the era of molecular taxonomy. Int J Infect Dis 2019;89:154-162.
Konishi T, Doki N, Kishida Y, Nagata A, Yamada Y, Kaito S, Kurosawa S, Yoshifuji K, Shirane S, Uchida T, Inamoto K, Toya T, Igarashi A, Najima Y, Kobayashi T, Kakihana K, Sakamaki H, Ohash K. Geriatric nutritional risk index (GNRI) just before allogeneic
hematopoietic stem cell transplantation predicts transplant outcomes in patients older than 50 years with acute myeloid leukemia in complete remission. Ann Hematol 2019;98(7):1799-1801.
De Marchi F, Araki M, Komatsu N. Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia. Expert Rev Hematol 2019;12(5):285-293.
Tsutsui M, Yasuda H, Ota Y, Komatsu N. Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis. Case Rep Oncol 2019;12(3):834-837.
Mori T, Watanabe N, Kitahara H, Iwao N, Koike M, Komatsu N. Acquired Factor VIII Inhibitor in a Patient of Rheumatoid Arthritis on Tumor Necrosis Factor Inhibitor Therapy. Indian J Hematol Blood Transfus 2019;35(1):192-193.
Morishita S, Ochiai T, Misawa K, Inano T, Fukuda Y, Kurokawa Y, Edahiro Y, Araki M, Ohsaka A, Komatsu N. Mutations in epigenetic and splicing related genes among japanese overt and prefibrotic primary myelofibrosis using target sequencing. The 10th JSH
INTERNATIONAL SYMPOSIUM 2019 in Ise-Shima, 鳥羽国際ホテル, May 17.
Kato S, Maekawa T, Ogata K, Osawa Y, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Kawamura T, Horiuchi T, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Komatsu N, Kimura F. SLAMF7high CD16negative Monocytes
Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation. 24th Congress of the European Hematology Association, Amsterdam, June 13-16.
Ishibashi M, Kinoshita R, Inokuchi K, Handa H, Sasaki M, Komatsu N, Imai Y, Hiroike N, Tanaka J, Tanosaki S, Ito S, Sunakawa M, Asayama T, Kuribayashi-hamada Y, Morita R, Tamura H. Serum Soluble CD86, Still a Prognostic Factor in the Novel Agent Era in
Multiple Myeloma Patients, Is Produced By Myeloma Cells with High CD86 Variant 3 Expression. American Society of Hematology, Orange County Convention Center (OCCC), Orlando, FL, USA, December 9.
枝廣陽子, 竹井拓, ChangLiu, 橳島麻衣, 森下総司, 大坂顯通, 荒木真理人, 小松則夫. The impact of allelic burden of JAK2V617F on human hematopoietic cell differentiation. 第29回日本サイトメトリー学会学術集会, 順天堂大学, 5月26日.
枝廣陽子. Clinical and molecular features of patients with prefibrotic/early primary myelofibrosis in a Japanese cohort. 第81回日本血液学会学術集会, 東京国際フォーラム, 10月12日.
Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia. 2018. [Epub ahead of print]
Watanabe N, Kitahara H, Iwao N, Ohta Y, Koike M, Komatsu N. Retroperitoneal relapse in an older patient with multiple myeloma during pomalidomide and dexamethasone treatment. Geriatr Gerontol Int. 2018;18(6):977-9.
Tokuhira M, Kimura Y, Sugimoto K, Nakazato T, Ishikawa M, Fujioka I, Takaku T, Iriyama N, Sato E, Fujita H, Hatta Y, Komatsu N, Asou N, Kizaki M, Kawaguchi T. Efficacy and safety of nilotinib therapy in patients with newly diagnosed chronic myeloid leukemia
in the chronic phase. Med Oncol. 2018;35(3):38.
Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N. Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor
cells harbouring calreticulin mutations. Br J Haematol. 2018;181(6):791-802.
Takaku T, Iriyama N, Mitsumori T, Sato E, Gotoh A, Kirito K, Noguchi M, Koike M, Sakamoto J, Oba K, Komatsu N. Clinical Efficacy and Safety of First-Line Dasatinib Therapy and the Relevance of Velocity of BCR-ABL1 Transcript Decline for Achievement of
Molecular Responses in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Report from the Juntendo Yamanashi Cooperative Study Group. Oncology. 2018;94(2):85-91.
Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, Kawaguchi T. Introduction of second-generation tyrosine kinase inhibitors may reduce the prognostic impact of high-risk
patients, according to the European treatment and outcome study (EUTOS) score. Leuk Lymphoma. 2018;59(5):1105-12.
Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K. Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis.
Curr Med Res Opin. 2018;34(3):531-7.
Ochiai T, Yasuda H, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N. The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: A comparison in a large-scale cohort. Eur J
Haematol. 2018;100(6):544-9.
Nitta H, Gotoh A, Tanaka M, Sekiguchi Y, Ota Y, Noguchi M, Komatsu N. Pleural effusion at diagnosis predicts extremely poor outcomes in patients with diffuse large B-cell lymphoma harbouring MYC rearrangement. Br J Haematol. 2018. [Epub ahead of print]
Nakazato T, Iriyama N, Tokuhira M, Ishikawa M, Sato E, Takaku T, Sugimoto KJ, Fujita H, Fujioka I, Kimura Y, Aisa Y, Iwanaga E, Asou N, Kizaki M, Hatta Y, Komatsu N, Kawaguchi T. Incidence and outcome of second malignancies in patients with chronic myeloid
leukemia during treatment with tyrosine kinase inhibitors. Med Oncol. 2018;35(7):99.
Nakamura A, Misawa S, Chonan M, Kawakami T, Horii T, Komatsu N, Ohsaka A. Efficacy of PCR-based open reading frame typing assay for outbreak investigation of metallo-beta-lactamase-producing Pseudomonas aeruginosa in hematology unit. J Infect Chemother.
2018. [Epub ahead of print]
Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N. Mutational subtypes of JAK2 and CALR correlate with different clinical features in Japanese patients with myeloproliferative neoplasms. Int J Hematol.
2018;107(6):673-80.
Kirito K, Okamoto S, Ohishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Oritani K, Akashi K, Okada H, Amagasaki T, Suzuki K, Yonezu T, Komatsu N. Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis. Int
J Hematol. 2018;107(1):92-7.
Inokuchi K, Nakayama K, Tauchi T, Takaku T, Yokose N, Yamaguchi H, Kumagai T, Komatsu N, Ohyashiki K. Therapeutic effects of tyrosine kinase inhibitors and subtypes of BCR-ABL1 transcripts in Japanese chronic myeloid leukemia patients with three-way chromosomal
translocations. Leuk Res. 2018;65:74-9.
Fujioka I, Takaku T, Iriyama N, Tokuhira M, Kimura Y, Sato E, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Asou N, Kizaki M, Hatta Y, Komatsu N, Kawaguchi T. Features of vascular adverse events in Japanese patients with chronic myeloid leukemia treated
with tyrosine kinase inhibitors: a retrospective study of the CML Cooperative Study Group database. Ann Hematol. 2018. [Epub ahead of print]
Asakura K, Azechi T, Sasano H, Matsui H, Hanaki H, Miyazaki M, Takata T, Sekine M, Takaku T, Ochiai T, Komatsu N, Shibayama K, Katayama Y, Yahara K. Rapid and easy detection of low-level resistance to vancomycin in methicillin-resistant Staphylococcus
aureus by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. PLoS One. 2018;13(3):e0194212.
Ishibashi M, Soeda S, Sasaki M, Handa H, Imai Y, Tanaka N, Tanosaki S, Ito S, Odajima T, Sugimori H, Asayama T, Sunakawa M, Kaito Y, Kinoshita R, Kuribayashi Y, Onodera A, Moriya K, Tanaka J, Tsukune Y, Komatsu N, Inokuchi K, Tamura H. Clinical impact
of serum soluble SLAMF7 in multiple myeloma. Oncotarget. 2018;9(78): 34784-34793.
Sakamoto K, Katayama R, Asaka R, Sakata S, Baba S, Nakasone H, Koike S, Tsuyama N, Dobashi A, Sasaki M, Ichinohasama R, Takakuwa E, Yamazaki R, Takizawa J, Maeda T, Narita M, Izutsu K, Kanda Y, Ohshima K, Takeuchi K. Recurrent 8q24 rearrangement in blastic
plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response. Leukemia. 2018 Dec;32(12):2590-2603.
英文症例報告
Edahiro Y, Ando J, Suzuki T, Fukumura Y, Masuda A, Sakayori S, Takeda J, Maruyama Y, Makino S, Itakura A, Komatsu N. Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia: A Case Report. Intern Med. 2018.
Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N. Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review. Histopathology. 2018;72(5):862-6.
Yamamoto T, Kamijo A, Nakazawa T, Nakajima K, Kirito K, Komatsu N, Masuyama K. A Very Rare Case of Hypereosinophilic Syndrome Secondary to Natural Killer/T-Cell Lymphoma. Case Rep Otolaryngol. 2018;2018:5965029.
Watanabe N, Gotoh A, Shirane S, Hamano Y, Hirai Y, Shimizu M, Nakamura A, Matsumoto K, Morita K, Mori T, Ohsaka A, Komatsu N. Breakthrough Exophiala dermatitidis infection during prophylactic administration of micafungin during second umbilical cord blood
transplantation after graft failure. Transpl Infect Dis. 2018;20(2):e12833.
海外学会発表
Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N. Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin. 23rd Congress of the European Hematology
Association. Stockholm, Sweden. June, 2018.
Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneda S, Ohsaka A, Araki M, Komatsu N. Copy number of JAK2V617F modulates human hematopoietic cell differentiation. 8th International Conference on Myeloproliferative Neoplasms; 2018 15-May; SAGGART(DUBLIN),
IRELAND.
Nitta H, Gotoh A, Tanaka M, Ochiai T, Ota Y, Komatsu N. The Presence of Pleural Effusion at Diagnosis Predicts Poor Outcomes in Diffuse Large B-Cell Lymphoma Patients with MYC-Rearrangement or Double Protein Expression. 59th Annual Meeting of the American
Society of Hematology and Exposition; 2017 11-Dec; Atlanta, USA.
Takaku T, Iriyama N, Mitsumori T, Sato E, Gotoh A, Kirito K, Noguchi M, Koike M, Sakamoto J, Oba K, Komatsu N. Clinical Efficacy and Safety of First-Line Dasatinib Therapy and the Relevance of Velocity of BCR-ABL1 Transcript Decline for Achievement of
Molecular Responses in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: Report from the Juntendo Yamanashi Cooperative Study Group. Oncology. 2017. [Epub ahead of print]
Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama
A, Takeishi Y. Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms. Blood Advances. 2017;1(15):1001-15.
Sunami Y, Araki M, Kan S, Ito A, Hironaka Y, Imai M, Morishita S, Ohsaka A, Komatsu N. Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia
Cells. J Biol Chem. 2017;292(7):2815-29.
Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, Kawaguchi T. Introduction of second-generation tyrosine kinase inhibitors may reduce the prognostic impact of high-risk
patients, according to the European treatment and outcome study (EUTOS) score. Leuk Lymphoma. 2017:1-8.
Sakurai H, Harada Y, Ogata Y, Kagiyama Y, Shingai N, Doki N, Ohashi K, Kitamura T, Komatsu N, Harada H. Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms. Blood Advances. 2017;1(18):1382-6.
Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N. The 2016 WHO diagnostic criteria for polycythemia vera renders an accurate diagnosis to a broader range of patients including
masked polycythemia vera: Comparison with the 2008 WHO diagnostic criteria. Am J Hematol. 2017;92(7):E128-e30.
Komatsu N, Kirito K, Shimoda K, Ishikawa T, Ohishi K, Ohyashiki K, Takahashi N, Okada H, Amagasaki T, Yonezu T, Akashi K. Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis. Int
J Hematol. 2017;105(3):309-17.
Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A,
Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M. A
nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Am J Hematol. 2017;92(12):1324-32.
Kitahara H, Maruyama D, Maeshima AM, Makita S, Miyamoto KI, Fukuhara S, Munakata W, Suzuki T, Kobayashi Y, Tajima K, Terauchi T, Kurihara H, Taniguchi H, Komatsu N, Tobinai K. Prognosis of patients with peripheral T cell lymphoma who achieve complete
response after CHOP/CHOP-like chemotherapy without autologous stem cell transplantation as an initial treatment. Ann Hematol. 2017;96(3):411-20.
Katayama Y, Azechi T, Miyazaki M, Takata T, Sekine M, Matsui H, Hanaki H, Yahara K, Sasano H, Asakura K, Takaku T, Ochiai T, Komatsu N, Chambers HF. Prevalence of Slow-growth Vancomycin Non-susceptibility In Methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2017;61(11):e00452-17.
Iriyama N, Tokuhira M, Takaku T, Sato E, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Fujioka I, Hatta Y, Kizaki M, Komatsu N, Asou N, Kawaguchi T. Incidences and outcomes of therapy-related chronic myeloid leukemia in the era of tyrosine kinase inhibitors:
Surveillance of the CML Cooperative Study Group. Leuk Res. 2017;54:55-8.
Ikuta K, Hatayama M, Addo L, Toki Y, Sasaki K, Tatsumi Y, Hattori A, Kato A, Kato K, Hayashi H, Suzuki T, Kobune M, Tsutsui M, Gotoh A, Aota Y, Matsuura M, Hamada Y, Tokuda T, Komatsu N, Kohgo Y. Iron overload patients with unknown etiology from national
survey in Japan. Int J Hematol. 2017;105(3):353-60.
Harrison CN, Koschmieder S, Foltz L, Guglielmelli P, Flindt T, Koehler M, Mathias J, Komatsu N, Boothroyd RN, Spierer A, Perez Ronco J, Taylor-Stokes G, Waller J, Mesa RA. The impact of myeloproliferative neoplasms (MPNs) on patient quality of life and
productivity: results from the international MPN Landmark survey. Ann Hematol.2017;96(10):1653-65.
Tanaka M, Tashiro H, Omer B, Lapteva N, Ando J, Ngo M, Mehta B, Dotti G, Kinchington PR, Leen AM, Rossig C, Rooney CM. Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells.
Clin Cancer Res.2017;23(14):3499-509.
Tsukune Y, Sasaki M, Odajima T, Sunami K, Takei T, Moriuchi Y, Iino M, Isoda A, Nakaya A, Muta T, Miyake T, Miyazaki K, Shimizu T, Nakajima K, Igarashi A, Nagafuji K, Kurihara T, Aoyama T, Sugimori H, Komatsu N. Incidence and risk factors of hepatitis
B virus reactivation in patients with multiple myeloma in an era with novel agents: a nationwide retrospective study in Japan. Blood Cancer J. 2017; 7(12): 631.
Saito A, Isoda A, Kojima M, Yokohama A, Tsukune Y, Sasaki M, Ito S, Ohtsu A, Koike M, Murayama K, Moriya K, Tamura H, Matsumoto M, Nakahashi H, Tanosaki S, Sakura T, Kawamura T, Miyanaga T, Nakamura N, Murakami H, Handa H, Tsukamoto N. Retrospective analysis
of prognostic factors for Waldenstrӧm macroglobulinemia: a multicenter cooperative study in Japan. Int J Hematol. 2017; 106(5): 681-690.
総説
Imai M, Araki M, Komatsu N. Somatic mutations of calreticulin in myeloproliferative neoplasms. Int J Hematol. 2017;105(6):743-7.
Araki M, Komatsu N. Novel molecular mechanism of cellular transformation by a mutant molecular chaperone in myeloproliferative neoplasms. Cancer Sci. 2017;108(10):1907-12.
Watanabe N, Yasuda H, Morishita S, Aota Y, Tomomatsu J, Tanaka M, Ohsaka A, Komatsu N. Richter's Syndrome with Hypercalcemia Induced by Tumor-Associated Production of Parathyroid Hormone-Related Peptide. Case Rep Oncol. 2017;10(1):123-6.
Sekiguchi Y, Wakabayashi M, Takizawa H, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. A case of Waldenstrom Macroglobulinemia in which intermittent one-day administration cycles of bendamustine were effective for alleviation
of nausea and maintenance of remission. J Clin Exp Hematop. 2017;57(2):79-81.
Sekiguchi Y, Takizawa H, Inano T, Fukuda Y, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. Three cases of relapsed/refractory multiple myeloma under hemodialysis treated with panobinostat/bortezomib/dexamethasone
(FVD). Int J Hematol.2017;106(4):581-7.
Ikeda K, Ueda K, Sano T, Ogawa K, Ikezoe T, Hashimoto Y, Morishita S, Komatsu N, Ohto H, Takeishi Y. The Amelioration of Myelofibrosis with Thrombocytopenia by a JAK1/2 Inhibitor, Ruxolitinib, in a Post-polycythemia Vera Myelofibrosis Patient with a JAK2
Exon 12 Mutation. Intern Med. 2017;56(13):1705-10.
Iizuka K, Ando J, Masuda A, Ochiai T, Tomomasa R, Yasuda H, Takaku T, Ota Y, Yao T, Gotoh A, Komatsu N. Acute exacerbation of organizing pneumonia leading to sudden death in a patient with sarcoidosis-lymphoma syndrome. Rinsho Ketsueki. 2017;58(8):927-32.
Ando J, Masuda A, Iizuka K, Ochiai T, Shingai N, Yasuda H, Homma Y, Kobayashi E, Morishita E, Komatsu N. Factor XI deficiency as a result of a novel Tyr347Stop nonsense mutation in an elderly Japanese woman. Geriatr Gerontol Int. 2017;17(6):1029-31.
Sano K, Homma Y, Baba T, Ando J, Matsumoto M, Kobayashi H, Yuasa T, Kaneko K. Total hip arthroplasty via the direct anterior approach with Kerboull-type acetabular reinforcement device for an elderly female with factor XI deficiency. Sicot j. 2017;3:11.
海外学会発表
Tsukune Y, Sasaki M, Odajima T, Isoda A, Sumami K, Takei T, Taniguchi H, Iino M, Nakaya A, Muta T, Miyake T, Miyazaki K, Shimizu T, Nakajima K, Igarashi A, Nagafuji K, Kurihara T, Uchino Y, Komatsu N, Hepatitis B virus reactivation in multiple myeloma
patients in the era of novel agents: a nationwide retrospective study in Japan. 16th International Myeloma Workshop,Delhi, India, March 2,2017.
Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N, editors. Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin
mutation in human cells. 22nd Congress of the European Hematology Association; 2017; Madrid; Spain.
Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Takei H, Edahiro Y, Ohsaka A, N. K, editors. Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity. 59th Annual Meeting of the
American Society of Hematology and Exposition; 2017; Atlanta, USA.
Sunakawa M, Tamura H, Ishibashi M, Sasaki M, Handa H, Imai Y, Tanaka J, Tanosaki S, Ito S, Inokuchi K. Clinical impact and possible immunosuppressive function of soluble B7-H1(PD-L1) in multiple myeloma. 16th International Myeloma Workshop, Delhi, March
3,2017.
Kaito Y, Tamura H, Soeda S, Asayama T, Ishibashi M, Sasaki M, Handa H, Imai Y, Tanaka J, Tanosaki S, Ito S, Inokuchi K. Serum soluble SLAMF7 with disease progression in multiple myeloma and may affect anti-SLAMF7 antibody therapy. 16th International Myeloma
Workshop, Delhi, India,March 2,2017.
高橋直人, 中世古知昭, 脇田久, 得平道英, 三谷絹子, 野口雅章, 木村文彦, 三浦昌朋: DMR and TFR following 2-year consolidation by Nilotinib in patients with CML: STAT trial in Japan, 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月20日
若林睦, 関口康宣, 坂尻さくら, 杉元啓二, 瀧澤春子, 飯塚弘子, 小松則夫, 野口雅章: Retrospective analysis of AE and manage in 23 patients treated with bendamustine at our department. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
瀧澤春子, 関口康宣, 坂尻さくら, 杉元啓二, 若林睦, 飯塚弘子, 小松則夫, 野口雅章: ET was difficult to differentiate from PMF/early that was treated with ruxolitinib, to preleukemia. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
野口雅章, 小松則夫, 小池道明, 木崎昌弘, 片山直之, 土橋史明, 薄井紀子, 桐戸敬太: Clinical Performance Study of a novel JAK2V617F mutation quantitative kits for patients with Ph-MPN. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
舛井嘉大, 関口康宣, 坂尻さくら, 杉元啓二, 若林睦, 瀧澤春子, 飯塚弘子, 小松則夫, 野口雅章: A primary bone marrow low grade B-cell lymphoma. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日.
Tsukune Y, Sasaki M, Sunami K, Suzuki K, Taniguchi H, Iino M, Isoda A, Nakaya A, Muta T, Miyake T, Miyazaki K, Shimizu T, Nakajima K, Igarashi A, Nagafuji K, Kurihara T, Uchino Y, Komatsu N. HBV reactivation in MM patients in the novel agents era: A nationwide
retrospective study in Japan., 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Tokuhira M, Kimura Y, Sugimoto K, Nakazato T, Ishikawa M, Fujioka I, Takaku T, Iriyama N, Sato E, Fujita H, Yoshihiro Hatta, Komatsu N, Asou N, Kizaki M, Kawaguchi T. Efficacy and safety of the reduced nilotinib therapy in patients with newly diagnosed
chronic myeloid leukemia. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Shingai N, Harada Y, Sakurai H, Ogata Y, Akahane K, Nishio M, Doki N, Ohashi K, Hagihara M, Komatsu N, Harada H. Splicing factor mutations may define the phenotypes and disease evolution of MDS. 第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto K, Fujita H, Fujioka I, Hatta Y, Kizaki M, Komatsu N, Asou N, Kawaguchi T. The introduction of 2nd generation TKIs may reduce the prognostic impact of EUTOS high-risk patients.
第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Kinoshita R, Ishibashi M, Inokuchi K, Handa H, Sasaki M, Komatsu N, Imai Y, Tanaka N, Tanaka J, Tanosaki S, Ito S, Isoda A, Matsumoto M, Koike M, Tamura H. Evalution of staging and prognostic factors in multiple myeloma:KT-MM prognostic analysis. 第79回日本血液学会学術集会;東京国際フォーラム
2017年10月21日
Nakazato T, Iriyama N, Ishikawa M, Sato E, Takaku T, Fujioka I, Sugimoto K, Fujita H, Kizaki M, Komatsu N, Asou N, Tokuhira M, Kawaguchi T. Incidence of Second Malignancies of Chronic Myeloid Leukemia During Treatment with Tyrosine Kinase Inhibitors.
第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Mizukami Y, Hironaka Y, Takei H, Morishita S, Kihara Y, Edahiro Y, Ohsaka A, Komatsu N. Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation. 第79回日本血液学会学術集会;東京国際フォーラム
2017年10月21日
Umezawa G, Ishibashi M, Tamura H, Asayama T, Kuribayashi-Hamada Y, Moriya K, Imai Y, Tanaka J, Handa H, Sasaki M, Tanosaki S, Ito S, Komatsu N, Inokuchi K. Clinical significance of CD86 soluble from and cell-surface expression in multiple myeloma patients.
第79回日本血液学会学術集会;東京国際フォーラム 2017年10月21日
Yoshimi A, Toya T, Nannya Y, Takaoka K, Kirito K, Ito E, Nakajima H, Hayashi Y, Takahashi T, Moriya-Saito A, Suzuki K, Harada H, Komatsu N, Usuki K, Ichikawa M, Kurokawa M. Spectrum of clinical and genetic features of patients with inherited platelet
disorder with suspected predisposition to hematological malignancies: a nationwide survey in Japan. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2016;27(5):887-95.
Tsukune Y, Komatsu N. Management of Adult Chronic Immune Thrombocytopenia in Japan: Patient and Hematologist Perspectives from a Multi-center Cross-sectional Questionnaire Survey. Internal medicine (Tokyo, Japan). 2016;55(17):2379-85.
Tsukune Y, Sasaki M, Odajima T, Isoda A, Matsumoto M, Koike M, Tamura H, Moriya K, Ito S, Asahi M, Imai Y, Tanaka J, Handa H, Koiso H, Tanosaki S, Hua J, Hagihara M, Yahata Y, Suzuki S, Watanabe S, Sugimori H, Komatsu N. Incidence and clinical background
of hepatitis B virus reactivation in multiple myeloma in novel agents' era. Annals of hematology. 2016;95(9):1465-72.
Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K, Morita Y, Nishiwaki K, Ninomiya H, Gotoh A, Imashuku S, Urabe A, Shichishima T, Nishimura J, Kanakura Y. Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with
eculizumab: a Japanese experience and updated review. International journal of hematology. 2016;103(6):703-12.
Mitsumori T, Komatsu N, Kirito K. A CSF3R T618I Mutation in a Patient with Chronic Neutrophilic Leukemia and Severe Bleeding Complications. Internal medicine (Tokyo, Japan). 2016;55(4):405-7.
Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O. Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma
Cell Death via Large Pore Formation. PloS one. 2016;11(3):e0150496.
Kobayashi Y, Saita Y, Nishio H, Ikeda H, Takazawa Y, Nagao M, Takaku T, Komatsu N, Kaneko K. Leukocyte concentration and composition in platelet-rich plasma (PRP) influences the growth factor and protease concentrations. Journal of orthopaedic science
: official journal of the Japanese Orthopaedic Association. 2016;21(5):683-9.
Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N. Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence. PloS one. 2016;11(5):e0156427.
Ichikawa K, Edahiro Y, Gotoh A, Iiduka K, Komatsu N, Koike M. Co-occurrence of hyperleukocytosis and elevated fibrin-fibrinogen degradation product levels is a risk factor for early intracranial hemorrhage in patients with de novo acute leukemia. International
journal of hematology. 2016;104(5):612-20.
Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N. MIP-1alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 2016;127(21):2607-17.
Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood.
2016;127(10):1307-16.
Yasuda H, Tsutsui M, Ota Y, Misawa K, Gotoh A, Hamano Y, Komatsu N. Blastic plasmacytoid dendritic cell neoplasm accompanied by autoimmune hemolytic anemia achieving complete remission with hydroxyurea and steroids. Geriatrics & gerontology international.
2016;16(3):396-8.
Tsukune Y, Sasaki M, Odajima T, Isoda A, Matsumoto M, Koike M, Tamura H, Moriya K, Ito S, Asahi M, Imai Y, Tanaka J, Handa H, Koiso H, Tanosaki S, Hua J, Hagihara M, Yahata Y, Suzuki S, Watanabe S, Sugimori H, Komatsu N. Incidence and clinical background
of hepatitis B virus reactivation in multiple myeloma in novel agents' era. Annals of hematology. 2016;95(9):1465-72.
Sunami Y, Ichikawa K, Edahiro Y, Komatsu N, Koike M. Safe and effective induction therapy with CHASER for primary testicular lymphoma with central nervous system involvement. Int J Clin Exp Med. 2016;9(9):18645-9.
Sekiguchi Y, Shirane S, Takizawa H, Wakabayashi M, Sugimoto KJ, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. T-cell lymphoma complicated by myelofibrosis: report of three cases and review of literature. Int J Clin Exp Pathol.
2016;9(8):7836-53.
Sekiguchi Y, Ichikawa K, Takizawa H, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Hirai T, Sekikawa I, Ohta Y, Komatsu N, Noguchi M. Epstein-Barr virus-negative and CD56-positive primary central nervous system lymphoproliferative
disorder (diffuse large B-cell lymphoma): a case of report and review of the literature. Int J Clin Exp Pathol. 2016;9(8):8017-26.
Sekiguchi Y, Inano T, Fukuda Y, Takizawa H, Wakabayashi M, Sugimoto KJ, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. A long-term favorable response and effective control of neutropenia obtained by low-dose pomalidomide treatment
in a patient with relapsed refractory multiple myeloma: a case report. Int J Clin Exp Med. 2016;9(11):22561-9.
Nakamura R, Ueno Y, Ando J, Matsuda H, Masuda A, Iiduka K, Shingai N, Takanashi M, Yokoyama K, Komatsu N, Hattori N. Clinical and radiological CLIPPERS features after complete remission of peripheral T-cell lymphoma, not otherwise specified. Journal of
the neurological sciences. 2016;364:6-8.
Mitsumori T, Komatsu N, Kirito K. A CSF3R T618I Mutation in a Patient with Chronic Neutrophilic Leukemia and Severe Bleeding Complications. Internal medicine (Tokyo, Japan). 2016;55(4):405-7.
Mohammad S, Gotoh A, Morishita S, Komatsu N. Imatinib-sensitive myeloid neoplasm with low allele burden of FIP1L1-PDGFRA fusion gene in an elderly patient. Geriatrics & gerontology international. 2016;16(12):1346-8.
Edahiro Y, Ichikawa K, Suzuki H, Yasuda H, Koike M, Komatsu N. Successful perioperative management of factor XI deficiency with administration of fresh-frozen plasma in a subdural hematoma patient. Geriatrics & gerontology international. 2016;16(1):143-4.
和文症例報告
Sunami Y, Gotoh A, Watanabe N, Edahiro Y, Hamano Y, Harada H, Komatsu N. [Chronic Myelomonocytic Leukemia with Myelofibrosis Resulting in Sudden Massive Pleural Effusion during Cytoreductive Therapy with Hydroxycarbamide]. Gan to kagaku ryoho Cancer &
chemotherapy. 2016;43(10):1223-6.
Ando J, Masuda A, Iizuka K, Ochiai T, Takaku T, Osawa T, Shimada E, Watanabe Y, Komatsu N, Osaka A. Congenital haptoglobin deficiency discovered on the occasion of anaphylaxis induced by platelet concentrate transfusion. [Rinsho ketsueki] The Japanese
journal of clinical hematology. 2016;57(12):2507-11.
Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms ,21st
EHA Congress, Copenhagen, Denmark, June 9-12, 2016.
Iriyama N, Takaku T, Sato E, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Tokuhira M, Kawaguchi T. Clinical Entity and Outcomes of Therapy-Related Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: Surveillance By the Chronic Myeloid
Leukemia Cooperative Study Group, 58th ASH Annual Meeting and Exposition, San Diego, USA, December 3-6, 2016.
Nishiwaki K, Sugimoto KJ, Tamaki S, Hisatake J, Yokoyama H, Igarashi T, Shinagawa A, Sugawara T, Hara S, Fujikawa K, Shimizu S, Toshiaki Y, Tojo A, Wakita H. Optimal Treatment Strategy with Nilotinib for Patients with Newly Diagnosed Chronic Myelogenous
Leukemia in the Chronic Phase Based on Early Achievement of Deep Molecular Response (MR4.5) : First Report from N-Road, a Phase II Study in Japan., 58th ASH Annual Meeting and Exposition, San Diego, USA, December 3-6, 2016.
Isobe Y, Masuda A, Sugimoto K, Komatsu N. The Long Form of Cellular FLIP Renders NK-Cell Lymphoma Cells Resistant to Fas-Mediated Apoptosis, 58th ASH Annual Meeting and Exposition, San Diego, USA, December 3-6, 2016.
池之内穣, 関口康宣, 杉元啓二, 若林睦, 瀧澤春子, 小松則夫, 野口雅章: BMではなくリンパ節と漿膜におけるIgAκ+ CD20+ CD19-形質細胞腫の典型的な1症例(A typical case of IgA kappa+ CD20+ CD19-plasmacytoma not in BM but in lymph node and serosa, 第56回日本リンパ網内系学会総会; ホテル日航熊本 2016年9月3日.
Okuda Y, Aota Y, Yokoyama T, Kitagawa N, Shinozawa K, Amano K, Fukutake K, Gotoh A, Komatsu N. Anticagulant therapy for a vein thrombosis Caucasian patient with the Factor V Leiden mutation. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Ochiai T, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami Y Gotoh A, Ohsaka A, Komatsu N. Clinical characteristics of BCSH criteria defined PV and ET patients in Japan. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Tsutsui M, Gotoh A, Araki M, Morishita S, Komatsu N. Impact of mutations on efficacy of anagrelide in Japanese patients with essential thrombocythemia. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Misawa K, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami Y, Gotoha A, Ohsaka A, Komatsu N. Differential clinical features by sbtypes of Calreticulin mutation in myeloproliferative neoplasms. , 第78回日本血液学会学術集会; パシフィコ横浜
2016年10月13-15日
Fujioka I, Takaku T, Watanabe N, Gotoh A, Komatsu N. Assessment of treatment response by international scale in Japanese patients with chronic phase CML. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Iizuka K, Andou J, Ochiai T, Shirane S, Masuda A, Gotoh A, Koike M, Komatsu N. Efficacy of GDP for anti-L-asparaginase antibody positive and /or SMILE resistant NK/T lymphpma. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Soeda S, Tamura H, Ishibashi M, Sasaki M, Handa H, Imai Y, Tanosaki S, Isoda A, Matsumoto M, Ito S, Koike M, Komatsu N, Inokuchi K. The impact of serum soluble SLAMF7 on myeloma pathogenesis and anti-SLAMF7 antibody-based therapy. , 第78回日本血液学会学術集会; パシフィコ横浜
2016年10月13-15日
Tsubota A, Tamura H, Ishibashi M, Sasaki M, Handa H, Imai Y, Tanosaki S, Isoda A, Matsumoto M, Ito S, Koike M, Komastu N, Inokuchi K. Clinical significance of serum soluble and plasma cell-surface SLAMF3 levels in multiple myeloma. , 第78回日本血液学会学術集会; パシフィコ横浜
2016年10月13-15日
Moriya K, Ishibashi M, Tamura H, Handa H, Sasaki M, Isoda A, Imai Y, Ito S, Tanosaki S, Inokuchi K, Komastu N, Matsumoto M, Tanaka J, Koike M. Clinical significance of IL-6 and IGF-1 receptor expression on myeloma cells. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Yamada A, Tamura H, Ishibashi M, Sasaki M, Komastu N, Handa H, Imai Y, Tanosaki S, Ito S, Isoda A, Matsumoto M, Koike M, Inokuchi K. An aggressive myeloma patient with high KL-6 production and clinical impact of serum KL-6 in myeloma. , 第78回日本血液学会学術集会;
パシフィコ横浜 2016年10月13-15日
Sugimoto K, Suzuki H, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H, Miyazono K, Komatsu N. Association of glutaminase high expression with L-asparaginase-sensitivity in lymphoid leukemia cells. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
瀧澤春子, 関口康宜, 若林睦, 杉元啓二, 小松則夫, 野口雅章: A Case of AE Free Remission of RRMM in Response to FVD during Maintenance Hemodialysis. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
小池道明, 飯塚和秀, 重光文子, 白根脩一, 小松則夫: Efficacy of cyclosporin A therapy for three cases of angioimmunoblastic T cell lymphoma (AITL), 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
佐藤恵理子, 野口雅章, 小池道明, 森下総司, 大津洋, 小松則夫: Stop trial against CMP-CP in CMR patients who had received sequential TKIs; an interim analysis. , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N. Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MPNs). , 第78回日本血液学会学術集会; パシフィコ横浜 2016年10月13-15日
Yasuda H, Tsutsui M, Tanaka M, Araki M, Morishita S, Sasaki M, Ohsaka A, Komatsu N. Accurate flow cytometric gating of the large lymphocyte region is a powerful screening method for detecting hairy cell leukemia presenting with a low tumor burden. Internal
medicine (Tokyo, Japan). 2015;54(10):1287-9. Epub 2015/05/20.
Yasuda H, Fujiwara N, Ishizaki Y, Komatsu N. Anemia attributed to vitamin B6 deficiency in post-pancreaticoduodenectomy patients. Pancreatology : official journal of the International Association of Pancreatology (IAP) [et al]. 2015;15(1):81-3. Epub 2014/12/30.
Sugimoto K, Suzuki HI, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H, Miyazono K, Komatsu N. A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines. Cancer science. 2015. Epub 2015/09/04.
Shirane S, Araki M, Morishita S, Edahiro Y, Takei H, Yoo Y, Choi M, Sunami Y, Hironaka Y, Noguchi M, Koike M, Noda N, Ohsaka A, Komatsu N. JAK2, CALR, and MPL mutation spectrum in Japanese patients with myeloproliferative neoplasms. Haematologica. 2015;100(2):e46-8.
Epub 2014/11/16.
Shirane S, Araki M, Morishita S, Edahiro Y, Sunami Y, Hironaka Y, Noguchi M, Koike M, Sato E, Ohsaka A, Komatsu N. Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential
thrombocythemia. International journal of hematology. 2015;101(2):148-53. Epub 2014/12/20.
Ohsaka A, Hirota-Komatsu S, Araki M, Komatsu N. Platelet-derived growth factor receptors form complexes with neuropilin-1 during megakaryocytic differentiation of thrombopoietin-dependent UT-7/TPO cells. Biochemical and biophysical research communications.
2015;459(3):443-9. Epub 2015/03/10.
Morishita S, Takahashi K, Araki M, Hironaka Y, Sunami Y, Edahiro Y, Tsutsui M, Ohsaka A, Tsuneda S, Komatsu N. Melting curve analysis after T allele enrichment (MelcaTle) as a highly sensitive and reliable method for detecting the JAK2V617F mutation.
PloS one. 2015;10(3):e0122003. Epub 2015/03/21.
Liew EL, Araki M, Hironaka Y, Mori S, Tan TZ, Morishita S, Edahiro Y, Ohsaka A, Komatsu N. Identification of AIM2 as a downstream target of JAK2V617F. Experimental hematology & oncology. 2015;5:2. Epub 2016/01/30.
Kummalue T, Inoue T, Miura Y, Narusawa M, Inoue H, Komatsu N, Wanachiwanawin W, Sugiyama D, Tani K. Ribosomal protein L11 and retinol dehydrogenase 11 induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells. Experimental
hematology. 2015. Epub 2015/04/02.
Hirokawa M, Sawada K, Fujishima N, Teramura M, Bessho M, Dan K, Tsurumi H, Nakao S, Urabe A, Fujisawa S, Yonemura Y, Kawano F, Oshimi K, Sugimoto K, Matsuda A, Karasawa M, Arai A, Komatsu N, Harigae H, Omine M, Ozawa K, Kurokawa M. Long-term outcome of
patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group. British journal of haematology. 2015. Epub 2015/03/27.
Harada-Shirado K, Ikeda K, Ogawa K, Ohkawara H, Kimura H, Kai T, Noji H, Morishita S, Komatsu N, Takeishi Y. Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms. British journal of haematology.
2015;168(3):338-49. Epub 2014/09/23.
2014年
英文原著
Shirane S, Araki M, Morishita S, Edahiro Y, Takei H, Choi M, Sunami Y, Hironaka Y, Noguchi M, Koike M, Noda N, Ohsaka A, Komatu N.：JAK2, CARL, and MPL mutation specterum in Japanese myeloproliferative neoplasms patients.：Haematologica, 2014; 99(5): 625-634
Aoki T, Izutsu K, Suzuki R, Nakaseko C, Arima H, Shimada K, Tomita A, Sasaki M, Takizawa J, Mitani K, Igarashi T, Maeda Y, Fukuhara N, Ishida F, Niitsu N, Ohmachi K, Takasaki H, Nakamura N, Kinoshita T, Nakamura S, Ogura M.：Prognostic significance of
pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan.：Haematologica, 2014; 99: 1817-1825
Yasuda H, Takaku T, Tomomatsu J, Hosone M, Tanaka H, Komatsu N.：Spontaneous Regression of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm Followed by Acute Monocytic Leukemia Evolving from Myelodysplastic Syndrome.：Intern Med, 2014; 53(23): 2717-2720.
Edahiro Y, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Kirito K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N.：JAK2V617F mutation status and allele burden in classical Ph-negative
myeloproliferative neoplasms in Japan.：Int J Hematol, 2014; 99: 625-634.
Komatsu N.：Guest editorial: Acute promyelocytic leukemia: change from "highly fatal to highly curable" leukemia.：Int J Hematol, 2014; 100: 16-17
Takei H, Morishita S, Araki M, Edahiro Y, Sunami Y, Hironaka Y, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Komatsu N. ：Detection of MPLW515L/K mutations and determination of allele frequencies with a single-tube PCR assay. ：PLOS ONE., 2014; 9(8): e104958
Koike M, Masuda A, Ichikawa K, Shigemitsu A, Komatsu N.：Plasmablastic lymphoma of the duodenal and jejunum.：Int J Clin Exp pathol, 2014; 15: 4479-4483
Lam K, Muselman A, Du R, Harada Y, Scholl AG, Yan M, Matsuura S, Weng S, Harada H, Zhang DE.：Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.：Blood, 2014; 124(14): 2203-2212
Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.：Hes1 promotes blast
crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.：Blood, 2014; 123(25): 3932-3942
Kimura Y, Gotoh A, Katagiri S, Hoshi Y, Uchida S, Yamasaki A, Takahashi Y, Fukutake K, Kiguchi T, Ohyashiki K.：Transfusion-transmitted hepatitis E in a patient with myelodysplastic syndromes.：Blood Transfus, 2014; 12(1): 103-106
Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T.：Hes1 upregulation contributes to the development
of FIP1L1-PDGRA-positive leukemia in blast crisis.：Exp Hematol, 2014; 42(5):369-379
Mitsumori T, Nozaki Y, Kawashima I, Yamamoto T, Shobu Y, Nakajima K, Morishita S, Komatsu N, Kirito K.：Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells. ：Exp Hematol, 2014; 42(9): 783-792
Ngo MC, Ando J, Leen AM, Ennamuri S, Lapteva N, Vera JF, Min-Venditti A, Mims MP, Heslop HE, Bollard CM, Gottschalk S, Rooney CM.：Complementation of antigen-presenting cells to generate T lymphocytes with broad target specificity.：J Immunother, 2014;
37(4): 193-203
Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H.：Impaired hematopoietic differentiation
of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.：Leukemia, 2014; 28(12): 2344-2354
Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A.：Ezh2 loss promotes development of myelodysplastic syndrome
but attenuates its predisposition to leukaemic transformation.：Nat Commun, 2014; 5: 4177
Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka H, Nakagawa M, Nannya Y, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Ichikawa M, Mano H, Kurokawa M.：Recurrent CDC25C mutations drive malignant transformation in FPD/AML.：Nat
Commun, 2014; 5: 4770
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.：A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and
Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature.：Indian J Hematol Blood Transfus, 2014; Suppl 1: 166-173.
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M.：Patient with refractory multiple myeloma developing eosinophilia after lenalidomide treatment and lung cancer 9 months later: case report and review
of the literature.：Indian J Hematol Blood Transfus, 2014; Suppl 1: 264-270
Sekiguchi Y, Yoshikawa H, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Ichinose T, Ozaki D, Komatsu N, Noguchi M.：Acquired factor v inhibitor developing after treatment with dabigatran etexilate methanesulfonate: a case report and
review of the literature.：Indian J Hematol Blood Transfus, 2014; Suppl 1: 275-279
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M.：Spontaneous regression of a clinically-advanced histologically low-grade follicular lymphoma involving the breast: case report and review of the literature.：Indian
J Hematol Blood Transfus, 2014; Suppl 1: 320-324
Ichikawa K, Noguchi M, Koike M, Aritaka N, Sekiguchi Y, Sunami Y, Tsutsui M, Hosone M, Hirano T, Gotoh A, Komatsu N.：Rituximab plus a CHOP-like regimen, central nervous system prophylaxis, and contralateral testicular irradiation for localized primary
testicular diffuse large B-cell lymphoma lead to prolonged progression-free survival.：Int J Hematol, 2014; 100(4): 370-378
Sugimoto KJ, Shimada A, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M.：T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.：Int J Clin Exp Pathol, 2014;
7(5): 2615-2623
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M.：A case of recurrent autoimmune hemolytic anemia during remission associated with acute pure red cell aplasia and hemophagocytic syndrome due to human
parvovirus B19 infection successfully treated by steroid pulse therapy with a review of the literature.：Int J Clin Exp Pathol, 2014; 7(5): 2624-2635
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M.：Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-CHOP therapy and intrathecal administration: a case report
and review of literature.：Int J Clin Exp Pathol, 2014; 7(6): 3363-3369
Sugimoto KJ, Shimada A, Ichikawa K, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M.：Primary platelet-derived growth factor-producing, spindle-shaped diffuse large B-cell lymphoma of the skull: a case report and literature review.：Int
J Clin Exp Pathol, 2014; 7(7): 4381-4390
Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Kinoshita A, Suga Y, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.：A case of post-mogamulizumab relapse of acute-type adult T-cell leukemia/lymphoma successfully treated
with mogamulizumab and etoposide.：Int J Clin Exp Pathol, 2014; 7(9): 6278-6290
Sekiguchi Y, Shimada A, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.：A case of secondary plasma cell leukemia resistant to novel agents, in which stringent complete remission was achieved and maintained
for a long period of time after VAD therapy and tandem autologous transplantation.：Int J Clin Exp Pathol, 2014; 7(9): 6313-6322
Wakabayashi M, Sekiguchi Y, Shimada A, Ichikawa K, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M：Diffuse large B-cell lymphoma solely involving bilateral adrenal glands and stomach: report of an extremely rare case
with review of the literature.：Int J Clin Exp Pathol, 2014; 7(11): 8190-8197
Sugimoto KJ, Asahina M, Shimada A, Ichikawa K, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M.：IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature.：Int J Clin
Exp Pathol, 2014; 7(12): 8980-8987
Ichikawa K, Noguchi M, Koike M, Aritaka N, Sekiguchi Y, Sunami Y, Tsutsui M, Hosone M, Hirano T, Gotoh A, Komatsu N.：Rituximab plus a CHOP-like regimen, central nervous system prophylaxis, and contralateral testicular irradiation for localized primary
testicular diffuse large B-cell lymphoma lead to prolonged progression-free survival.：Int J Hematol, 2014; 100(4): 370-378
Sakurai H, Sugimoto KJ, Shimada A, Imai H, Wakabayashi M, Sekiguchi Y, Ota Y, Izutsu K, Takeuchi K, Komatsu N, Noguchi M.：Primary CNS CCND1/MYC-Positive Double-Hit B-Cell Lymphoma: A Case Report and Review of the Literature.：J Clin Oncol, 2014; Mar 31.
Mor A, Ueno Y, Shimura H; Sekiguchi Y, Noguchi M, Hamada Y, Kusunoki S, Kuroki T, Kambe T, Nishioka K, Hoshino Y, Hattori N, Urabe T.：Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle
cell lymphoma.：J Neurol Sci, 2014; 337(1-2): 215-218
Sugimoto KJ, Shimada A, Wakabayashi M, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Komatsu N, Noguchi M：CD56-positive adult T-cell leukemia/lymphoma: a case report and a review of the literature.：Med Mol Morphol, 2014;
Ichikawa K, Aritaka N, Ogura K, Komatsu N, Hirano T.：Strongly suspicious hemolysis caused by azacitidine in a myelodysplastic syndrome patient. ：Geriatr Gerontol Int, 2014; 14: 1006-1007
Sugimoto KJ, Shimada A, Ichikawa K, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M.：Primary platelet-derived growth factor-producing, spindle-shaped diffuse large B-cell lymphoma of the skull: a case report and literature review.：Int
J Clin Exp Pathol, 2014; 7: 4381-4390
Koike M, Masuda A, Ichikawa K, Shigemitu A, Komatus N.：Plasmablastic lasmablastic lymphoma of the duodenal and jejunum. ：Int J Clin Exp Pathol, 2014; 7: 4479-4483
Wakabayashi M, Sekiguchi Y, Shimada A, Ichikawa K, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.：Diffuse large B-cell lymphoma solely involving bilateral adrenal glands and stomach: report of an extremely rare case
with review of the literature.：Int J Clin Exp Pathol, 2014; 7: 8190-8197
Sugimoto KJ, Asahina M, Shimada A, Ichikawa K, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M.：IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature. ：Int J Clin
Exp Pathol, 2014; 7: 8980-8987.
Sakurai H, Sugimoto S, Asami Shimada Hidenori Imai, Mutsumi Wakabayashi, Yasunori Ota and Koji Izutsu Kengo Takeuchi Norio Komatsu Masaaki Noguchi.：Primary CNS CCND1/MYC-Positive Double-Hit B-Cell Lymphoma: A Case Report and Review of the Literature.：J
Clin Oncol, 2014; Mar 31.
Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew E.L, Edahiro Y, Tsutsui M, Ohsaka M, Komatsu N. Inhibition of the NAD dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. Plos One, 2013; 8(2):
e57633
Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H. RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
Blood, 2013; 121(17): 3434-46
Yakura Y, Ishihara C, Kurosaki H, Kazuki Y, Komatsu N, Okada Y, Doi T, Takeya H, Oshimura M. An induced pluripotent stem cell-mediated and integration-free factor VIII expression system. Biochem Biophys Res Commun. 2013; 431(2): 336-341
Saito F, Hatano T, Hori M, Kawamura M, Sasaki M, Aoki S, Hattori N. Lateral and dorsal column hyperintensity on magnetic resonance imaging in a patient with myelopathy associated with intrathecal chemotherapy. Case Rep Neurol, 2013; 5: 110-115
Tokuhira M, Takezako N, Nakazato T, Sasaki M, Handa T, Ikuta K, Ikezoe T, Matsumoto M, Aotsuka N, Taguchi J, Shimomura S, Chin K, Ichikawa K, Usuki K, Ohyashiki K, Nara M, Kishi K, Kuroda Y, Nakamura Y, Yokoyama A, Kamata H, Ichikawa Y, Hattori Y, Akazawa
K, Murakami H, Uchimaru K, Tomoyasu S, Suzuki K, Kizaki M. Interrim analysis of clinical trial of MBP followed by bortezomib maintenance therapy for elderly patients with ND-MM. Clin Lymphoma Myeloma Leuk, 2013; 13(S1): s146
Nozaki Y, Mitsumori T, Yamamoto T, Kawashima I, Shobu Y, Hamanaka S, Nakajima K, Komatsu N, Kirito K. Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels. Exp Hematol, 2013; 41(8): 687-696
Imagawa J, Harada Y, Shimomura T, Tanaka H, Okikawa Y, Harada H. High early death rate in elderly patients with acute promyelocytic leukemia treated with all-trans retinoic acid combined chemotherapy. Int J Hematol, 2013; 98(2): 264-266
Morikawa D, Nojiri H, Saita Y, Kobayashi K, Watanabe K, Ozawa Y, Koike M, Asou Y, Takaku T, Kaneko K, Shimizu T. Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading. J Bone Miner Res, 2013; 28(11): 2368-2380
Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura
T. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest, 2013; 123(11): 4627-4640
Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N. A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation. J Clin Virol, 2013; 56(2): 150-152
Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N. MIP-1 α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia. J Exp Med, 2013; 210(12): 2661-2673
Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes. Leukemia, 2013; 27(10): 2107-2111
Shimada A, Sugimoto KJ, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Komatsu N, Noguchi M. Primary sacral non-germinal center type diffuse large B-cell lymphoma with MYC translocation: a case report and a review of the literature.
Int J Clin Exp Pathol, 2013; 6(9): 1919-1928
Sugimoto KJ, Shimada A, Yamaguchi N, Imai H, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M. Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose
DeVIC therapy and radiation therapy: a case report and review of the literature. Int J Clin Exp Pathol, 2013; 6(11): 2603-2608
Sugimoto KJ, Imai H, Shimada A, Wakabayashi M, Sekiguchi Y, Nakamura N, Sawada T, Izumi H, Ota Y, Komatsu N, Noguchi M. Diffuse large B-cell lymphoma of the uterus suspected of having transformed from a marginal zone B-cell lymphoma harboring trisomy
18: a case report and review of the literature. Int J Clin Exp Pathol, 2013; 6(12): 2979-2988
Sugimoto KJ, Shimada A, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Takeuchi K, Ito Y, Kimura H, Komatsu N, Noguchi M. A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia
and cytotoxic T-cell lymphoma. Int J Clin Exp Pathol, 2013; 7(1): 411-417
Sugimoto KJ, Shimada A, Sakurai H, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Izumi H, Ota Y, Komatsu N, Noguchi M. Primary gingival diffuse large B-cell lymphoma: a case report and a review of the literature. Int J Clin Exp Pathol, 2013;
7(1): 418-424
Sekiguchi Y, Matsuzawa N, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Izutsu K, Takeuchi K, Ohta Y, Komatsu N, Noguchi M. Angioimmunoblastic T-cell lymphoma with intramedullary production of platelet-derived growth factor and possibly
complicating myelofibrosis: report of a case with review of the literature. Int J Hematol, 2013; 98(2): 250-257
Sekiguchi Y, Asahina T, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M. A case of extramedullary plasmablastic plasmacytoma successfully treated using a combination of thalidomide and dexamethasone and a review
of the medical literature. J Clin Exp Hematop, 2013; 53(1): 21-28
Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M. CD56+ angioimmunoblastic T-cell lymphoma with evans syndrome : a case report and review of the literature. J Clin Exp Hematop, 2013; 53(1): 37-47
Sekiguchi Y, Yoshikawa H, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Takeuchi K, Ohta Y, Komatsu N, Noguchi M. Primary hepatic circumscribed Burkitt's lymphoma that developed after acute hepatitis B: report of a case with a review
of the literature. J Clin Exp Hematop, 2013; 53(2): 167-173
Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. Computational dissection of distinct microRNA activity signatures associated with peripheral T-cell lymphoma subtypes. Leukemia, 2013; 27(10): 2107-2111
Sasaki M, Sugimoto K. Entral nervous system recurrence in the primary mediastinal large B-cell lymphoma. Tumors of the Central Nervous System, Springer, 2013; 9
Ichikawa K, Noguchi M, Masuda M, Tsutsui M, Sugimoto K, Sekiguchi Y, Imai H, Wakabayashi M, Komatsu N. CD4(+) CD8(-) T cell large granular lymphocytic leukaemia with central nervous system involvement. Histopathology. 60(3): 519-522, 2012
Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N. T/NK cell type chronic active Epstein-Barr virus disease in adults: an underlying condition for Epstein-Barr virus-associated T/NK-cell lymphoma. J Clin Pathol. 65(3):278-282,
2012
Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N. Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell Lymphoma, nasal type (ENKL): differences in biologic and clinical behaviors of LMP1-positive
and -negative ENKL. Clin Cancer Res. 18(8):2164-2172, 2012
Isobe Y, Tomomatsu J, Tsukune Y, Tsukada N, Sasaki M, Sugimoto K, Komatsu N. Diagnostic Problems Among Chronic Lymphocytic Leukemia and Other Indolent B-cell Leukemias in a Japanese Population. Intern Med. 51(15): 1977-1981, 2012
Tsutsui M, Koike M, Komatsu N. Fulminant hepatitis possibly caused by L-asparaginase during induction chemotherapy in a patient with acute lymphoblastic leukemia. Rinsho Ketsueki. 53(5):531-4. Japanese. 2012
Tomomatsu J, Hamano Y, Ando J, Komatsu N, Sugimoto K. Non-myeloablative allogenic BMT for myelodysplastic syndrome successfully controlled accompanying relapsing polychondritis. Bone Marrow Transplant. 47(5):742-743, 2012
Sekiguchi Y, Shirane S, Imai H, Sugimoto K, Wakabayashi M, Sawada T, Chigira N, Ichikawa K, Komatsu N, Noguchi M. Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review
of the literature. Intern Med. 51(11):1393-1398, 2012
Aritaka N, Ichikawa K, Nakamura H, Yasuda H, Ogura K, Matsumoto T, Komatsu N, Hirano T. Attainment of a stringent complete response in multiple myeloma with thalidomide monotherapy. Intern Med. 51(19): 2781-2783, 2012
2011年
Ichikawa K, Noguchi M, Imai H, Sekiguchi Y, Wakabayashi M, Sawada T, Komatsu N. A case of T cell prolymphocytic leukemia involving blast transformation. Int J Hematol. 93(5):667-672, 2011
Ichikawa K, Sugimoto K, Sato E, Sunami Y, Watanabe N, Ushimi T, Komatsu N. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography revealed the presence of simultaneous colon cancer in mucosa-associated lymphoid tissue lymphoma. Geriatr
Gerontol Int. 11(4): 537-538, 2011
Sasaki M, Sugimoto K, Masuda A, Tsukune Y, Yahata Y, Komatsu N. Early CNS relapse in a good-risk primary mediastinal large B-cell lymphoma after combined chemo- and radio-therapy. J Neurooncol. 99(2): 295-296, 2011
Yasuda H, Aritaka N, Ando J, Hirama M, Komatsu N, Hirano T. Chonic myelogenous leukemia with mild basophilia as the predominant manifestation at presentation. Intern Med. 50(5):501-502, 2011
Tabe Y, Kawase Y, Miyake K, Satoh N, Aritaka N, Isobe Y, Oshimi K, Komatsu N, Miida T, Ohsaka A. Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis. Clin Chem Lab Med. 49(5):809-815, 2011
Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, Miura Y, Okada M, Suehiro Y, Takahashi A, Marumoto T, Inoue H, Komatsu N, Tani K. APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans. Stem
Cell Rev. Stem Cell Rev. 7(1): 43-52, 2011
Sekiguchi Y, Imai H, Wakabayashi M, Sawada T, Ichikawa K, Komatsu N, Noguchi M. CD5-Positive Follicular Lymphoma: A Case Report and Literautre Review. Intern Med. 50: 1-6, 2011
Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K. miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. Blood 118(26):6881-6892, 2011
Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, Noda N. Alternately binding probe competitive PCR as a simple, cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms. Leuk Res.
35(12):1632-1636, 2011
Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada JI, Fujiwara S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H. Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of epstein-barr virus infection. Int J Cancer.
129(9): 2263-2273, 2011
Sunami Y, Sato E, Ichikawa K, Yasuda H, Komatsu N. Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase. Rinsho Ketsueki. 52(5): 282-286, Japanese. 2011
Takagi S, Komatsu N. Risk-benefit assessment in management of adult idiopathic thrombocytopenic purpura. Rinsho Ketsueki. 52(11): 1751-1758, Japanese. 2011
