研究

Index
現時点での最良の治療法を提供することはいうまでもありませんが、将来に向けててんかんの病態や効果的な治療方法などを研究していくことは、大学病院であり、てんかんセンターである私たちの使命であると考えます。

研修プログラムおよびカンファレンス

毎週月曜日18:00-18:45で行っています。
参加者：脳外科、脳神経内科、小児科、メンタルクリニック、脳波技師、ME、看護師、神経心理士
毎回1～3名の症例検討および学会発表の予演、今後の研究についての議論を行っています。
参加される先生はオープンカンファレンスですので、てんかんセンター　脳神経外科　飯村（yiimura@juntendo.ac.jp）にお問い合わせください。

研究テーマ

  1. イノベーション創発に資する人工知能基盤技術の創出と統合化 脳波の機械判読によるてんかん診断・治療支援 AIの構築 (JST CREST)
  2. 人間と情報環境の共生インタラクション基盤技術の創出と展開 (JST CREST)
  3. 拡散MRIと機能MRIによる機械学習を用いた運動機能ネットワーク可塑性の解明 (文部科学省 科学研究 基盤C)
  4. 稀少てんかんに関する調査研究 (厚生労働省 科学研究 難治性疾患等政策研究事業)
  5. 成人二次性側頭葉てんかんに対する新たな病態解析と糖蛋白の発現調整の新治療応用 (文部科学省 科学研究 基盤C)
  6. 頭皮脳波高周波律動と徐波のCoupling解析による生理機能とてんかん原生の解明 (文部科学省 科学研究 スタート支援)

業績（論文）

2020年

  1. Mitsuhashi T, Sonoda M, Iwaki H, Luat AF, Sood S, Asano E. Effects of depth electrode montage and single-pulse electrical stimulation sites on neuronal responses and effective connectivity. Clinical Neurophysiology.2020 Oct 14;131(12):2781-2792.
  2. Mitsuhashi T, Sugano H, Iimura Y, et al. Passive functional mapping - Neurological disorders and examination. Clinical Neuroscience 2020;38(7):926-8.
  3. Mitsuhashi T, Sugano H, Asano K, Nakajima T, Nakajima M, Okura H, Iimura Y, Suzuki H, Tange Y, Tanaka T, Aoki S, Arai H. Functional MRI and Structural Connectome Analysis of Language Networks in Japanese-English Bilinguals. Neuroscience. 2020 Apr 1;431:17-24
  4. Okanari K, Maruyama S, Suzuki H, Shibata T, Pulcine E, Donner EJ, Otsubo H. Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures. Epilepsy Behav. 2020 Jan;102:106688.

2019年

  1. Suzuki H, Sugano H, Nakajima M, Higo T, Iimura Y, Mitsuhashi T, Fusegi K, Kakita A, Otsubo H, Arai H.
    The epileptogenic zone in pharmaco-resistant temporal lobe epilepsy with amygdala enlargement.
    Epileptic Disord. 2019 Jun 1;21(3):252-264
  2. Andica C, Hagiwara A, Hori M, Haruyama T, Fujita S, Maekawa T, Kamagata K, Yoshida MT, Suzuki M, Sugano H, Arai H, Aoki S.
    Aberrant myelination in patients with Sturge-Weber syndrome analyzed using synthetic quantitative magnetic resonance imaging. Neuroradiology. 2019 Sep;61(9):1055-1066
  3. Andica C, Hagiwara A, Hori M, Kamagata K, Koshino S, Maekawa T, Suzuki M, Fujiwara H, Sugano H, Arai H, Aoki S.
    Review of synthetic MRI in pediatric brains: Basic principle of MR quantification, its features, clinical applications, and limitations.
    J Neuroradiol. 2019 Jul;46(4):268-275
  4. Iimura Y, Sugano H, Nakajima M, Higo T, Suzuki H, Mitsuhashi T, Ueda T, Karagiozov K, Igarashi A, Otsubo H, Arai H.
    Is decremental modulation index on scalp EEG a sign of good seizure outcome? A Sturge-Weber syndrome case with epileptic spasms. Clin Neurophysiol. 2019 Sep;130(9):1499-1501
  5. Hayashi K, Jin K, Nagamori C, Okanari K, Okanishi T, Homma Y, Iimura Y, Uda T, Takada L, Otsubo H.
    Sudden unexpected death in epilepsy in the bathtub. Epilepsy Behav. 2019 Jul;96:33-40
  6. 上田 哲也, 飯村 康司, 三橋 匠, 鈴木 皓晴, 菅野 秀宣, 新井 一
    てんかん外科治療後に精神症状を顕在化したために術後早期に抗てんかん薬を減量した一例 てんかん研究 2019 年 37 巻 1 号 p. 60-66
  7. Noboru Yoshida, Yoshiteru Arai, Yuriha Kasai, Yoshiyuki Ohtomo, Shinichi Niijima, Toshiaki Shimizu. West syndrome associated with glycogen storage disease type 1b. Epilepsy & Seizure. 2019 Sep 5; 11(1): 446-51
  8. Iida K, Kagawa K, Katagiri M, Seyama G, Hashizume A, Abiko M, Katayama J, Suzuki H, Kurisu K, Otsubo H. Preservation of Memory Despite Unresected Contralateral Hippocampal Volume Loss After Resection of Hippocampal Sclerosis in Seizure-Free Patients. World Neurosurg. 2019 Dec;132:e759-e765.

2018年

  1. Iimura Y, Jones K, Takada L, Shimizu I, Koyama M, Hattori K, Okazawa Y, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC 3rd, Donner EJ, Rutka JT, Drake JM, Otsubo H.
    Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms; Investigation of Modulation Index and Occurrence Rate.
    Epilepsia. 59(3):544-554. 2018
  2. Chougar L, Hagiwara A, Maekawa T, Hori M, Andica C, Sugano H, Aoki S.
    Limitation of neurite orientation dispersion and density imaging for the detection of focal cortical dysplasia with a "transmantle sign". Phys Med. 2018 Aug;52:183-184.
  3. Mata-Mbemba D, Iimura Y, Hazrati LN, Ochi A, Otsubo H, Snead OC 3rd, Rutka J, Widjaja E.
    MRI, Magnetoencephalography, and Surgical Outcome of Oligodendrocytosis versus Focal Cortical Dysplasia Type I. AJNR Am J Neuroradiol. 2018 Dec;39(12):2371-2377.

2017年

  1. Ikeno M, Abe S, Kurahashi H, Takasu M, Shimizu T, Okumura A. Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. Brain.Dev.2017 39(4):356-360.
  2. Iimura Y, Jones K, Hattori K, Okazawa Y, Noda A, Hoashi K, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC 3rd, Donner EJ, Rutka JT, Drake JM, Otsubo
    Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy. Clinical Neurophysiology. 128(7):1197-1205. 2017
  3. Sato Y, Simeon WM, Iimura Y, Ochi A, Sam MD, Otsubo H
    Spatiotemporal changes of multiscale entropy in gamma oscillations associated with focal ictogenesis Sci Rep. 2017 Aug 24;7(1):9362.
  4. Inoue T, Kawawaki H, Fukuoka M, Kim K, Nukui M, Kuki I, Okazaki S, Koh S, Kunihiro N, Uda T, Matsuzaka Y, Matsuhashi M, Iimura Y, Otsubo H
    Intraoperative CCEP shows disconnection of the motor cortex from the epileptogenic network during subtotal hemispherotomy Clinical Neurophysiology 29(2):455-457, 2017

2016年

  1. Okumura A, Abe S, Kurahashi H, Takasu M, Ikeno M, Nakazawa M, Igarashi A, Shimizu T. Worsening of attitudes toward epilepsy following less influential media coverage of epilepsy-related car accidents: An infodemiological approach. Epilepsy Behav. 2016 64(Pt A):206-211.
  2. Higo T,  Sugano H, Nakajima M, Karagiozov K, Iimura Y, Suzuki M, Sato K, Arai H. The predictive value of FDG-PET with 3D-SSP for surgical outcomes in patients with temporal lobe epilepsy. Seizure. 2016 41:127-33.
  3. Iimura Y, Sugano H, Nakajima M, Higo T, Suzuki H, Nakanishi H, Arai H. Analysis of Epileptic Discharges from Implanted Subdural Electrodes in Patients with Sturge-Weber Syndrome. PLoS One. 2016 11(4): e0152992.
  4. Andica C, Hagiwara A, Nakazawa M, Tsuruta K, Takano N, Hori M, Suzuki H,  Sugano H, Arai H, Aoki S. The Advantage of Synthetic MRI for the Visualization of Early White Matter Change in an Infant with Sturge-Weber Syndrome. Magn Reson Med Sci. 2016 11;15(4):347-348.
  5. Hagiwara A, Nakazawa M, Andica C, Tsuruta K, Takano N, Hori M, Sugano H, Arai H, Aoki S. Dural Enhancement in a Patient with Sturge-Weber Syndrome Revealed by Double Inversion Recovery Contrast Using Synthetic MRI. Magn Reson Med Sci. 2016;15(2):151-2.
  6. Ayuko IGARASHI, Akihisa OKUMURA, Keiko SHIMOJIMA, Shinpei ABE,  Mitsuru IKENO, Toshiaki SHIMIZU, Toshiyuki YAMAMOTO Focal seizures and epileptic spasms in a child with Down syndrome from a family with a PRRT2 mutation Brain & Development 38 (2016) 597-600．

2015年

  1. Sugano H, Arai H. Epilepsy surgery for pediatric epilepsy: optimal timing of surgical intervention. Neurol Med Chir (Tokyo). 2015;55(5):399-406.
  2. Nakazawa M, Toda S, Abe S,  Ikeno M, Igarashi A, Nakahara E, Yamashita S, Niijima S, Shimizu T, Okumura A.: Efficacy and safety of fosphenytoin for benign convulsions with mild gastroenteritis.,Brain Dev. 2015 Feb 20. pii: S0387-7604(15)00026-1.
  3. Yamamoto T, Shimojima K, Sangu N, Komoike Y, Ishii A, Abe S, Yamashita S, Imai K, Kubota T, Fukasawa T, Okanishi T, Enoki H, Tanabe T, Saito A, Furukawa T, Shimizu T, Milligan CJ, Petrou S, Heron SE, Dibbens LM, Hirose S, Okumura A.: Single Nucleotide Variations in CLCN6 Identified in Patients with Benign Partial Epilepsies in Infancy and/or Febrile Seizures.,PLoS One. 2015 Mar 20;10(3):e0118946.

2014年

  1. Okumura A, Abe S, Nakazawa M, Ikeno M, Igarashi A, Takasu M, Shimizu T. Attitudes toward driver's licenses for people with epilepsy: 2012 versus 2014. Pediatr Int. 2017 59(2):185-189.
  2. Ohno K, Saito Y, Togawa M, Shinohara Y, Ito T, Sugano H, Itamura S, Nishimura Y, Tamasaki A, Maegaki Y :Evolution of a symptomatic diffuse developmental venous anomaly with progressive cerebral atrophy in an atypical case of  Sturge-Weber syndrome., Brain Dev. 2014 Dec 26. pii: S0387-7604(14)00288-5.
  3. Nakashima M, Miyajima M, Sugano H, Iimura Y, Kato M, Tsurusaki Y, Miyake N, Saitsu H, Arai H, Matsumoto N.: The somatic GNAQ mutation c.548G> A(p.R183Q) is consistently found in Sturge-Weber syndrome., J Hum Genet. 2014 Dec;59(12):691-3.
  4. Sugano H, Nakanishi H, Nakajima M,  Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H.: Posterior quadrant disconnection surgery for Sturge-Weber syndrome., Epilepsia. 2014 May;55(5):683-9.
  5. Nakajima M, Sugano H, Iimura Y, Higo T, Nakanishi H, Shimoji K, Karagiozov K, Miyajima M, Arai H: Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood. J Neurosurg Pediatrics 2014.13: 90-93
  6. Igarashi A, Okumura A, Komatsu M, Tomita O, Abe S,  Ikeno M, Saito M, Nakazawa T, Shimizu T.: Amplitude-integrated EEG revealed nonconvulsive status epilepticus in children with non-accidental head injury.,Eur J Paediatr Neurol. 2014 Nov;18(6):806-10.
  7. Okumura A, Nakazawa M, Shimizu T.: Is attitude toward epilepsy and driving affected by media coverage?, Pediatr Int. 2014 Oct;56(5):759-62.