研究・学会活動

• 【解説書】神谷和作　AAVベクターを用いた内耳への遺伝子治療
  神谷和作
  実験医学別冊　決定版　ウイルスベクターによる遺伝子導入実験ガイド
  Page159-166(2020.11)
• Ichiro Fukunaga, Kyoko Shirai, Yoko Oe, Keiko Danzaki, Sayaka Ohta,Takahiro Shiga, Cheng Chen, Katsuhisa Ikeda, Wado Akamatsu, AtsushiKawano, Kazusaku Kamiya
  Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss
  Stem Cell Research, 2020; 47:101910.
• Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya
  Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss.
  Experimental and Molecular Medicine, 2020 ;52(1):166-175.
  (日本経済新聞　2020年3月9日　他)
• 神谷 和作
  【解説/特集】難聴を治す-2020年版　感音難聴と遺伝子治療
  JOHNS耳鼻咽喉科・頭頸部外科, 2020, 36, 1, 97-100.
• Fukunaga I, Shiga T, Chen C, Oe Y, Danzaki K, Ohta S, Matsuoka R, Anzai T, Hibiya-Motegi R, Tajima S, Ikeda K, Akamatsu W, Kamiya K.
  Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation.
  Stem Cell Research, 2019, 4;43:101674.
• Fukunaga I, Fujimoto A, Hatakeyama K, Kurebayashi N, Ikeda K, Kamiya K.
  Generation of Functional CX26-Gap-Junction-Plaque-Forming Cells with Spontaneous Ca2+ Transients via a Gap Junction Characteristic of Developing Cochlea.
  Current Protocols in Stem Cell Biology, 2019; 51(1):e100.
• 神谷和作
  【解説/特集】内耳と免疫　内耳基礎研究の新展開を求めて　内耳ケモカイン発現を応用した内耳組織への多能性幹細胞誘導法の開発
  耳鼻咽喉科免疫アレルギー 2018, 36(3), 229-231
• 神谷和作
  【解説】蝸牛ギャップ結合を標的とした遺伝性難聴の創薬と治療法の開発
  Otology Japan, 2018, 28( 2), 79-81.
• Matsuoka R, Lee S, Sato M, Hibiya R, Shimanuki Y, Kasai M, Kamiya K, Itakura A, Koike T, Ikeda K.
  Piezoelectric vibrator-stimulated potential and heart rate accelerations detected from the fetus. Int J Pediatr Otorhinolaryngol. 2017;101:204-210.
• Ichiro Fukunaga, Ayumi Fujimoto, Kaori Hatakeyama, Toru Aoki, Atena Nishikawa, Tetsuo Noda, Osamu Minowa, Nagomi Kurebayashi, Katsuhisa Ikeda, Kazusaku Kamiya (corresponding author)
  In vitro models of GJB2-related hearing loss recapitulate Ca2+ transients via a gap junction characteristic of developing cochlea
  Stem Cell Reports, 2016, 7(6), 1023-1036
  （読売新聞、英The Sun、米Fox News　他）
• Kazusaku Kamiya
  Inner ear cell therapy targeting hereditary deafness by activation of stem cell homing factors.
  Frontiers in Pharmacology 2015;6:2.
• Takashi Anzai, Ichiro Fukunaga, Kaori Hatakeyama, Ayumi Fujimoto, Kazuma Kobayashi, Atena Nishikawa, Toru Aoki, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda, Kazusaku Kamiya. (corresponding author)
  Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice.
  PLoS One, 2015, 10(10):e0141258.
• 神谷和作　(解説/特集)【内耳研究最前線1】 蝸牛イオン輸送に不可欠なコネキシンによる新たな生化学機構
  Otology Japan (0917-2025)25巻2号 Page119-122(2015.05)
• Kazusaku Kamiya, Ichiro Fukunaga, Kaori Hatakeyama, Katsuhisa Ikeda
  Connexin26 regulates assembly and maintenance of cochlear gap junction macromolecular complex for normal hearing
  AIP Conf. Proc. 1703, 030018 (2015); http://dx.doi.org/10.1063/1.4939333
• Takashi Iizuka, Kazusaku Kamiya, Satoru Gotoh, Yoshinobu Sugitani, Masaaki Suzuki, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda, Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness.
  Hum Mol Genet. 2015, 24(13):3651-61.
  (朝日新聞、日経新聞、読売新聞、NHKニュース　2015年4月7日)
• Kamiya K, Karasawa K, Kobayashi K, Miwa A, Ikeda K
  Differentiation of iPS Cells to Cochlear Cells are Regulated Depending on the Part of Co-cultured Organs.
  J Otol Rhinol, 2015, S1:1. doi:10.4172/2324-8785.S1-008
• Okada H, Kamiya K, Iizuka T, Ikeda K
  Postnatal Development and Maturation of the Vestibular Organ in Dominant-Negative Connexin 26 Transgenic Mouse.
  J Otol Rhinol, 2015, S1:1. doi:10.4172/2324-8785.S1-009
• Yoshinobu Kidokoro, Keiko Karasawa, Osamu Minowa, Yoshinobu Sugitani, Tetsuo Noda, Katsuhisa Ikeda, Kazusaku Kamiya (corresponding author)
  Deficiency of Transcription Factor Brn4 Disrupts Cochlear Gap Junction Plaques in a Model of DFN3 Non-Syndromic Deafness.
  PLoS One. 2014;9(9):e108216.
• Kazusaku Kamiya, Vincent Michel, Fabrice Giraudet, Brigitte Riederer, Isabelle Foucher, Samantha Papal, Isabelle Perfettini, Sebastien Le Gal, Elisabeth Verpy, Weiliang Xia, Ursula Seidler, Maria-Magdalena Georgescu, Paul Avan, Aziz El-Amraouia, Christine Petit
  An unusually powerful mode of low-frequency sound interference due to outer hair cell hair bundle defects unveiled in Nherf1-/- mice
  Proc Natl Acad Sci U S A. 2014, 111(25):9307-12.
  （科学新聞2014年7月4日他）
• Kazusaku Kamiya (corresponding author), Sabrina W. Yum, Nagomi Kurebayashi, Miho Muraki, Kana Ogawa, Keiko Karasawa, Asuka Miwa, Xueshui Guo, Satoru Gotoh, Yoshinobu Sugitani, Hitomi Yamanaka, Shioko Ito-Kawashima, Takashi Iizuka, Takashi Sakurai, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda
  Assembly of the cochlear gap junction macromolecular complex requires Connexin26
  Journal of Clinical Investigation 2014;124(4):1598-1607.
  (日経産業新聞、時事通信他、2014年3月4日)
• Sakuraba M, Murata J, Teruyama R, Kamiya K, Yamaguchi J, Okano H, Uchiyama Y, Ikeda K. Spatiotemporal expression of TRPM4 in the mouse cochlea.
  J Neurosci Res. 2014 92(10):1409-18.
• Ayako Inoshita, Keiko Karasawa, Megumi Funakubo, Asuka Miwa, Katsuhisa Ikeda, Kazusaku Kamiya (corresponding author)
  Dominant negative connexin26 mutation R75W causing severe hearing loss　influences normal programmed cell death in postnatal organ of Corti
  BMC genetics 2014, 15(1):1-8
• Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sakaki S, Uchida S
  Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice.
  Biochem Biophys Res Commun. 2013;441(3):544-9
• 神谷和作【革新的難聴治療の夜明け】遺伝性難聴への内耳細胞治療法開発
  Cell therapy for hereditary hearing loss with stem cell homing factors.
  日本薬理学雑誌2013;141(4):191-4.
• Gianluca Esposito, Sachine Yoshida, Ryuko Ohnishi, Yousuke Tsuneoka, Maria del Carmen Rostagno, Susumu Yokota, Shota Okabe,
  Kazusaku Kamiya, Mikio Hoshino, Masaki Shimizu, Paola Venuti, Takefumi Kikusui, Tadafumi Kato, Kumi O. Kuroda
  Infant Calming Responses During Maternal Carrying In Humans and Mice Current Biology, 2013 23(9):739-45.
• Hiroko Okada, Takashi Iizuka, Hideki Mochizuki, Tomoko Nihira, Kazusaku Kamiya, Ayako Inoshita, Hiromi Kasagi, Misato Kasai, Katsuhisa Ikeda, Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors
  Otology & Neurotology, 2012.33(4):655-9
• 神谷和作　池田勝久
  【幹細胞治療-基礎研究の進歩と臨床応用-】 臨床応用の進歩　多能性幹細胞を用いた遺伝性難聴に対する内耳細胞治療法の開発
  Inner ear cell therapy for hereditary deafness with multipotent stem cells
  日本臨床　特集・幹細胞治療　2011 (12):2215-9.
• Hayashi C, Funayama M, Li Y, Kamiya K, Kawano A, Suzuki M, Hattori N, Ikeda K.
  Prevalence of GJB2 causing recessive profound non-syndromic deafness in Japanese children.
  Int J Pediatr Otorhinolaryngol. 2011;75(2):211-4.
• Yan D, Kamiya K, Ouyang XM, Liu XZ.
  Analysis of subcellular localization of Myo7a, Pcdh15 and Sans in Ush1c knockout mice.
  Int J Exp Pathol. 2011 92(1):66-71.
• Kasai M, Hayashi C, Iizuka T, Inoshita A, Kamiya K, Okada H, Nakajima Y, Kaga K, Ikeda K.
  Vestibular function of patients with profound deafness related to GJB2 mutation.
  Acta Otolaryngol. 2010 130(9):990-5.
• 神谷和作、池田勝久　実験動物を用いた内耳細胞治療研究へのアプローチ
  耳鼻咽喉科臨床(2010)補126:1-5
• Fujinami Y, Mutai H, Kamiya K, Mizutari K, Fujii M, Matsunaga T.
  Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid.
  Neurochem Int. 2010 56(3):487-94.
• 神谷和作
  難聴に対する細胞治療法の開発
  医学のあゆみ　特集号・細胞治療Update, 2009 Vol229, No.9, 863-867
• Kamiya K
  Cell therapy targeting cochlear fibrocytes,
  Otology Japan 2009, 19(3):214-218
• Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T,
  Kamiya K, Okamura HO, Shinkawa H,　Ikeda K
  Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission,
  Neuroscience 2009;164(3):1312-9

2020年2月28日　順天堂大学プレスリリース

2016年11月11日　順天堂大学プレスリリース

2015年4月6日　順天堂大学プレスリリース

2014年6月13日　順天堂大学プレスリリース

2014年3月3日　順天堂大学プレスリリース、日経プレスリリース

日本医療研究開発機構（AMED）研究費

日本私立学校振興・共済事業団

厚生労働科学研究費

各財団

文部科学省科学研究費補助金